ArticlePeerJ2017
Characterization of adipose tissue macrophages and adipose-derived stem cells in critical wounds.
Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Research update of adipose tissue-based therapies in regenerative dermatology.Stem cell reviews and reports · 2022Review
- Glycine is a competitive antagonist of the TNF receptor mediating the expression of inflammatory cytokines in 3T3-L1 adipocytes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Article
- Human Macrophages Preferentially Infiltrate the Superficial Adipose Tissue.International journal of molecular sciences · 2018Article
- Sequential drug delivery to modulate macrophage behavior and enhance implant integration.Advanced drug delivery reviewsReview
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSubcutaneous adipose tissue is a rich source of adipose tissue macrophages and adipose-derived stem cells which both play a key role in wound repair. While macrophages can be divided into the classically-activated M1 and the alternatively-activated M2 phenotype, ASCs are characterized by the expression of specific stem cell markers.
methodsIn the present study, we have investigated the expression of common macrophage polarization and stem cell markers in acutely inflamed adipose tissue. Subcutaneous adipose tissue adjacent to acutely inflamed wounds of 20 patients and 20 healthy subjects were harvested and underwent qPCR and flow cytometry analysis.
resultsExpression levels of the M1-specific markers CD80, iNOS, and IL-1b were significantly elevated in inflammatory adipose tissue when compared to healthy adipose tissue, whereas the M2-specific markers CD163 and TGF- DISCUSSION: This is the first report describing the predominance of M1 adipose tissue macrophages and the reduction of stem cell marker expression in acutely inflamed, non-healing wounds.
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Registered trials
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