ArticleNutrition & metabolism2017
Plasticity of adipose tissue in response to fasting and refeeding in male mice.
Article in Nutrition & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 70 citations in OpenAlex.
- Weight Loss Induces Changes in Vitamin D Status in Women With Obesity But Not in Men: A Randomized Clinical Trial.The Journal of clinical endocrinology and metabolism · 2025Trial
- Intermittent fasting promotes remodeling of neural and vascular networks in visceral white adipose tissue.iScience · 2026Article
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- Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling.Cell reports · 2025Article
- A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation.Cell metabolism · 2025Article
- Effects of time-restricted feeding (TRF)-model of intermittent fasting on adipose organ: a narrative review.Eating and weight disorders : EWD · 2024Review
- A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation.bioRxiv : the preprint server for biology · 2024Article
- Metabolic programming of organ-specific natural killer cell responses.Immunological reviews · 2024Review
- Intermittent Fasting Sustainably Improves Glucose Tolerance in Normal Weight Male Mice Through Histone Hyperacetylation.Journal of the Endocrine Society · 2023Article
- Plasticity of adipose tissues in response to fasting and refeeding declines with aging in mice.Aging · 2023Article
- Beyond energy balance regulation: The underestimated role of adipose tissues in host defense against pathogens.Frontiers in immunology · 2023Review
- Review
- Global Loss of Core 1-DerivedInternational journal of molecular sciences · 2022Article
- Identifying Key Genes and Functionally Enriched Pathways of Diverse Adipose Tissue Types in Cattle.Frontiers in genetics · 2022Article
- Nutritional Regulation of Mammary Tumor Microenvironment.Frontiers in cell and developmental biology · 2022Review
- Article
- Insulin action in adipocytes, adipose remodeling, and systemic effects.Cell metabolism · 2021Review
- Circulating levels of IL-33 are elevated by obesity and positively correlated with metabolic disorders in Chinese adults.Journal of translational medicine · 2021Article
- Long Non-coding RNA 332443 Inhibits Preadipocyte Differentiation by Targeting Runx1 and p38-MAPK and ERK1/2-MAPK Signaling Pathways.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFasting is the most widely prescribed and self-imposed strategy for treating excessive weight gain and obesity, and has been shown to exert a number of beneficial effects. The aim of the present study was to determine the exact role of fasting and subsequent refeeding on fat distribution in mice.
methodsC57/BL6 mice fasted for 24 to 72 h and were then subjected to refeeding for 72 h. At 24, 48 and 72 h of fasting, and 12, 24, 48 and 72 h of refeeding, the mice were sacrificed, and serum and various adipose tissues were collected. Serum biochemical parameters, adipose tissue masses and histomorphological analysis of different depots were detected. MRNA was isolated from various adipose tissues, and the expressions of thermogenesis, visceral signature and lipid metabolism-related genes were examined. The phenotypes of adipose tissues between juvenile and adult mice subjected to fasting and refeeding were also compared.
resultsFasting preferentially consumed mesenteric fat mass and decreased the cell size of mesenteric depots; however, refeeding recovered the mass and morphology of inguinal adipose tissues preferentially compared with visceral depots. Thermogenesis-related gene expression in the inguinal WAT and interscapular BAT were suppressed. Mitochondrial biogenesis was affected by fasting in a depot-specific manner. Furthermore, a short period of fasting led to an increase in visceral signature genes (
conclusionsFasting preferentially consumes lipids in visceral adipose tissues, whereas refeeding recovers lipids predominantly in subcutaneous adipose tissues, which indicated the significance of plasticity of adipose organs for fat distribution when subject to food deprivation or refeeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.