Evidence map›Paper›PMID 28070194›Full record

ReviewStem cells international2016

Muse Cells: Nontumorigenic Pluripotent Stem Cells Present in Adult Tissues-A Paradigm Shift in Tissue Regeneration and Evolution.

Ariel A Simerman, Julia D Phan, Daniel A Dumesic, Gregorio D Chazenbalk

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06141317 (Tissue Regeneration and Function Recovery in Patients With Parkinson's Disease Using Allogenic Pluripotent Stem Cells Isolated From Adipose Tissue), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06141317 phase1 / phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

Tissue Regeneration and Function Recovery in Patients With Parkinson's Disease Using Allogenic Pluripotent Stem Cells Isolated From Adipose Tissue (PASCs): A Randomized Phase I/IIa Clinical Trial (REPOSE)

TypeinterventionalSponsorClusterXStem-Costa RicaRan2023 to 2024Enrolled40ConditionsParkinson DiseaseArmsPASC transplantation (25 million PASCs/patient), Control
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ariel A SimermanDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at The University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-3844-5091
Julia D PhanDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at The University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-2439-816X
Daniel A DumesicDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at The University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-0387-1277
Gregorio D ChazenbalkDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at The University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-2065-3343
University of California, Los Angeles · US

Funding

PROJECT 4: ANDROGEN EXCESS IN ADIPOGENIC DYSFUNCTION IN PCOS WOMENP50HD071836 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI DUMESIC, DANIEL A · 2014 to 2021
$14.7M
NICHD NIH HHS P50 HD071836
6 · The paper itself

Abstract

Muse cells are a novel population of nontumorigenic pluripotent stem cells, highly resistant to cellular stress. These cells are present in every connective tissue and intrinsically express pluripotent stem markers such as Nanog, Oct3/4, Sox2, and TRA1-60. Muse cells are able to differentiate into cells from all three embryonic germ layers both spontaneously and under media-specific induction. Unlike ESCs and iPSCs, Muse cells exhibit low telomerase activity and asymmetric division and do not undergo tumorigenesis or teratoma formation when transplanted into a host organism. Muse cells have a high capacity for homing into damaged tissue and spontaneous differentiation into cells of compatible tissue, leading to tissue repair and functional restoration. The ability of Muse cells to restore tissue function may demonstrate the role of Muse cells in a highly conserved cellular mechanism related to cell survival and regeneration, in response to cellular stress and acute injury. From an evolutionary standpoint, genes pertaining to the regenerative capacity of an organism have been lost in higher mammals from more primitive species. Therefore, Muse cells may offer insight into the molecular and evolutionary bases of autonomous tissue regeneration and elucidate the molecular and cellular mechanisms that prevent mammals from regenerating limbs and organs, as planarians, newts, zebrafish, and salamanders do.

Identifiers

PMID28070194
PMCPMC5192335
OpenAlexW2563041945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.