ArticleMolecular psychiatry2017
An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry.
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Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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24citing papers in PubMed, 2 pooled it
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24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders.Molecular psychiatry · 2023Pooled it
- Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies.BMC medical genetics · 2017Pooled it
- Lifespan Trajectories of Resting State EEG power.bioRxiv : the preprint server for biology · 2026Article
- Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence.Research square · 2024Article
- Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies.Molecular psychiatry · 2023Review
- The collaborative study on the genetics of alcoholism: Brain function.Genes, brain, and behavior · 2023Review
- Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features.Behavioral sciences (Basel, Switzerland) · 2023Article
- A genome-wide association study of tinnitus reveals shared genetic links to neuropsychiatric disorders.Scientific reports · 2022Article
- Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population.Alcoholism, clinical and experimental research · 2022Article
- Targeting prefrontal cortex GABAergic microcircuits for the treatment of alcohol use disorder.Frontiers in synaptic neuroscience · 2022Review
- Imaging Genetics in Epilepsy: Current Knowledge and New Perspectives.Frontiers in molecular neuroscience · 2022Review
- A scoping review of electroencephalographic (EEG) markers for tracking neurophysiological changes and predicting outcomes in substance use disorder treatment.Frontiers in human neuroscience · 2022Article
- Predicting risk for Alcohol Use Disorder using longitudinal data with multimodal biomarkers and family history: a machine learning study.Molecular psychiatry · 2021Article
- Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans.Brain sciences · 2020Review
- Human brain arousal in the resting state: a genome-wide association study.Molecular psychiatry · 2019Article
- CR-19-0950: Event-related responses to alcohol-related stimuli in Mexican-American young adults: Relation to age, gender, comorbidity and "dark side" symptoms.Drug and alcohol dependence · 2019Article
- Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans.Genes, brain, and behavior · 2019Article
- Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.Genes, brain, and behavior · 2019Article
- Conflict-related medial frontal theta as an endophenotype for alcohol use disorder.Biological psychology · 2018Article
- Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity.Human brain mapping · 2018Article
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Authors and funding
31 authors.
J L MeyersDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
J ZhangDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
J C WangDepartment of Neuroscience, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J SuDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
S I KuoDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
M KapoorDepartment of Neuroscience, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
L WetherillDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
S BertelsenDepartment of Neuroscience, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
D LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
J E SalvatoreDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
C KamarajanDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
D ChorlianDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
A AgrawalDepartment of Psychiatry, Washington University School of Medicine in St Louis, St Louis, MO, USA.
L AlmasyDepartment of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
L BauerDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
K K BucholzDepartment of Psychiatry, Washington University School of Medicine in St Louis, St Louis, MO, USA.
G ChanDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
V HesselbrockDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
L KogantiDepartment of Neuroscience, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J KramerDepartment of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
S KupermanDepartment of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
N ManzDepartment of Physics, The College of Wooster, Wooster, OH, USA.
A PandeyDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
M SeayDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
D ScottCollaborative Alcohol Research Center, Howard University College of Medicine, Washington, DC, USA.
R E TaylorCollaborative Alcohol Research Center, Howard University College of Medicine, Washington, DC, USA.
D M DickDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
H J EdenbergDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
A GoateDepartment of Neuroscience, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
T ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
B PorjeszDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7MWashington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MInfectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MDELINEATING THE ROLE OF GENETIC INFLUENCES ON CANNABIS INVOLVEMENTK02DA032573 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA · 2012 to 2021
$1.1MGenetics, Romantic Relationships, and Alcohol Misuse in Emerging AdulthoodK01AA024152 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALVATORE, JESSICA E · 2016 to 2020
$741kGene-Environment Interaction for Cannabis Use Disorders in Blacks and Whites in the U.S.K01DA037914 · NIDA · SUNY DOWNSTATE MEDICAL CENTER · PI MEYERS, JACQUELYN LEIGH · 2015 to 2019
$573kNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NCRR NIH HHS UL1 RR024992NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004438NIAAA NIH HHS K01 AA024152NIAAA NIH HHS L30 AA022519NIAAA NIH HHS U10 AA008401NIAID NIH HHS T32 AI007172NIDA NIH HHS K01 DA037914NIDA NIH HHS K02 DA032573NIDA NIH HHS L30 DA042455NIH HHS S10 OD018522
Abstract
Fast beta (20-28 Hz) electroencephalogram (EEG) oscillatory activity may be a useful endophenotype for studying the genetics of disorders characterized by neural hyperexcitability, including substance use disorders (SUDs). However, the genetic underpinnings of fast beta EEG have not previously been studied in a population of African-American ancestry (AA). In a sample of 2382 AA individuals from 482 families drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed a genome-wide association study (GWAS) on resting-state fast beta EEG power. To further characterize our genetic findings, we examined the functional and clinical/behavioral significance of GWAS variants. Ten correlated single-nucleotide polymorphisms (SNPs) (r
Indexed as
ElectroencephalographyEndophenotypesGenetic Predisposition to DiseaseAdultAlcohol DrinkingAlcoholismBlack or African AmericanBlack PeopleBrainButyrylcholinesteraseFemaleGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideButyrylcholinesterase
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