Evidence map›Paper›PMID 28070000›Full record

ArticleStroke2017

Anesthesia Technique and Outcomes of Mechanical Thrombectomy in Patients With Acute Ischemic Stroke.

Kimon Bekelis, Symeon Missios, Todd A MacKenzie, Stavropoula Tjoumakaris, Pascal Jabbour

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 6 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 127 citations in OpenAlex.

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  17. Association of local anesthesia versus conscious sedation with functional outcome of acute ischemic stroke patients undergoing embolectomy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Kimon BekelisFrom the Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA (K.B., S.T., P.J.); The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH (K.B., T.A.M.); Neuroscience Institute, Cleveland Clinic/Akron General Hospital, OH (S.M.); and Department of Medicine (T.A.M.) and Department of Community and Family Medicine (T.A.M.), Dartmouth-Hitchcock Medical Center, Lebanon, NH. kbekelis@gmail.com.
Symeon MissiosFrom the Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA (K.B., S.T., P.J.); The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH (K.B., T.A.M.); Neuroscience Institute, Cleveland Clinic/Akron General Hospital, OH (S.M.); and Department of Medicine (T.A.M.) and Department of Community and Family Medicine (T.A.M.), Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Todd A MacKenzieFrom the Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA (K.B., S.T., P.J.); The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH (K.B., T.A.M.); Neuroscience Institute, Cleveland Clinic/Akron General Hospital, OH (S.M.); and Department of Medicine (T.A.M.) and Department of Community and Family Medicine (T.A.M.), Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Stavropoula TjoumakarisFrom the Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA (K.B., S.T., P.J.); The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH (K.B., T.A.M.); Neuroscience Institute, Cleveland Clinic/Akron General Hospital, OH (S.M.); and Department of Medicine (T.A.M.) and Department of Community and Family Medicine (T.A.M.), Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Pascal JabbourFrom the Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA (K.B., S.T., P.J.); The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH (K.B., T.A.M.); Neuroscience Institute, Cleveland Clinic/Akron General Hospital, OH (S.M.); and Department of Medicine (T.A.M.) and Department of Community and Family Medicine (T.A.M.), Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Akron General Medical Center · USCleveland Clinic · USDartmouth Institute for Health Policy and Clinical Practice · US

Funding

SYNERGY: The Dartmouth Center for clinical and Translational ScienceUL1TR001086 · NCATS · DARTMOUTH COLLEGE · PI GREEN, ALAN I · 2013 to 2017
$18.3M
Technology Diffusion, Health Outcomes, and Healthcare ExpendituresU01AG046830 · NIA · DARTMOUTH COLLEGE · PI SKINNER, JONATHAN S · 2013 to 2017
$4.5M
NCATS NIH HHS UL1 TR001086NIA NIH HHS U01 AG046830
6 · The paper itself

Abstract

background and purposeThe impact of anesthesia technique on the outcomes of mechanical thrombectomy for acute ischemic stroke remains an issue of debate. We investigated the association of general anesthesia with outcomes in patients undergoing mechanical thrombectomy for ischemic stroke.

methodsWe performed a cohort study involving patients undergoing mechanical thrombectomy for ischemic stroke from 2009 to 2013, who were registered in the New York Statewide Planning and Research Cooperative System database. An instrumental variable (hospital rate of general anesthesia) analysis was used to simulate the effects of randomization and investigate the association of anesthesia technique with case-fatality and length of stay.

resultsAmong 1174 patients, 441 (37.6%) underwent general anesthesia and 733 (62.4%) underwent conscious sedation. Using an instrumental variable analysis, we identified that general anesthesia was associated with a 6.4% increased case-fatality (95% confidence interval, 1.9%-11.0%) and 8.4 days longer length of stay (95% confidence interval, 2.9-14.0) in comparison to conscious sedation. This corresponded to 15 patients needing to be treated with conscious sedation to prevent 1 death. Our results were robust in sensitivity analysis with mixed effects regression and propensity score-adjusted regression models.

conclusionsUsing a comprehensive all-payer cohort of acute ischemic stroke patients undergoing mechanical thrombectomy in New York State, we identified an association of general anesthesia with increased case-fatality and length of stay. These considerations should be taken into account when standardizing acute stroke care.

Indexed as

AgedAged, 80 and overAnesthesia, GeneralBrain IschemiaCohort StudiesFemaleHumansLength of StayMaleMechanical ThrombolysisMiddle AgedNew YorkProcedural SedationStrokeTreatment Outcomeacute ischemic strokegeneral anesthesiainstrumental variablemechanical thrombectomySPARCS

Identifiers

PMID28070000
PMCPMC5263179
OpenAlexW2570778470

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.