ArticleToxicological sciences : an official journal of the Society of Toxicology2017
Exposure to Concentrated Ambient PM2.5 Shortens Lifespan and Induces Inflammation-Associated Signaling and Oxidative Stress in Drosophila.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Systematic Mapping and Review of Landscape Fire Smoke (LFS) Exposure Impacts on Insects.Environmental entomology · 2022Pooled it
- Modifying Role of Sustainable Diets on the Association Between Particulate Matter and Biological Aging: The Guangzhou Biobank Cohort Study.Aging cell · 2026Article
- Chemical composition, seasonal variability and source identification of PM2.5 in an urban background site in Medellín-Colombia.PloS one · 2026Article
- Effects of Particulate Matter on Obstructive Sleep Apnea and Obesity.Journal of rhinology : official journal of the Korean Rhinologic Society · 2025Review
- Depressed nestling growth during exposure to smoke from distant wildfires.Scientific reports · 2025Article
- Mendelian randomization study supports the causal effects of air pollution on longevity via multiple age-related diseases.npj aging · 2023Article
- Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestations.Frontiers in public health · 2023Article
- The utility of alternative models in particulate matter air pollution toxicology.Current research in toxicology · 2022Article
- 2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells.Molecules (Basel, Switzerland) · 2021Article
- Chronic exposure to ambient particulate matter induces gut microbial dysbiosis in a rat COPD model.Respiratory research · 2020Article
- Exposure to PMLipids in health and disease · 2019Article
- Air Pollution Alters Caenorhabditis elegans Development and Lifespan: Responses to Traffic-Related Nanoparticulate Matter.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Developmental programming of obesity by maternal exposure to concentrated ambient PMParticle and fibre toxicology · 2019Article
- Concentrated ambient PMPeerJ · 2019Article
- Effect of PM2.5 environmental pollution on rat lung.Environmental science and pollution research international · 2018Article
- Exposure to concentrated ambient PMParticle and fibre toxicology · 2018Article
- Exposure to Concentrated Ambient PM2.5 Compromises Spermatogenesis in a Mouse Model: Role of Suppression of Hypothalamus-Pituitary-Gonads Axis.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Concentrated Ambient PMEnvironmental health perspectives · 2018Article
- Curcumin pretreatment protects against PM2.5‑induced oxidized low‑density lipoprotein‑mediated oxidative stress and inflammation in human microvascular endothelial cells.Molecular medicine reports · 2017Article
- Genome-wide transcriptional analysis of cardiovascular-related genes and pathways induced by PMEnvironmental science and pollution research international · 2017Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Exposure to ambient PM 2.5 is associated with human premature mortality. However, it has not yet been toxicologically replicated, likely due to the lack of suitable animal models. Drosophila is frequently used in longevity research due to many incomparable merits. The present study aims to validate Drosophila models for PM 2.5 toxicity study through characterizing their biological responses to exposure to concentrated ambient PM 2.5 (CAP). The survivorship curve demonstrated that exposure to CAP markedly reduced lifespan of Drosophila. This antilongevity effect of CAP exposure was observed in both male and female Drosophila, and by comparison, the male was more sensitive [50% survivals: 20 and 48 days, CAP- and filtered air (FA)-exposed males, respectively; 21 and 40 days, CAP- and FA-exposed females, respectively]. Similar to its putative pathogenesis in humans, CAP exposure-induced premature mortality in Drosophila was also coincided with activation of pro-inflammatory signaling pathways including Jak, Jnk, and Nf-κb and increased systemic oxidative stress. Furthermore, like in humans and mammals, exposure to CAP significantly increased whole-body and circulating glucose levels and increased mRNA expression of Ilp2 and Ilp5 , indicating that CAP exposure induces dysregulated insulin signaling in Drosophila. Similar to effects on humans exposure to CAP leads to premature mortality likely through induction of inflammation-associated signaling, oxidative stress, and metabolic abnormality in Drosophila, strongly supporting that it can be a useful model organism for PM 2.5 toxicity study.
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Registered trials
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