Evidence map›Paper›PMID 28069965›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis.

Marc-André Lécuyer, Olivia Saint-Laurent, Lyne Bourbonnière, Sandra Larouche, Catherine Larochelle, Laure Michel, Marc Charabati, Michael Abadier, Stephanie Zandee, Neda Haghayegh Jahromi and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 103 citations in OpenAlex.

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  15. Establishment of a novel amyotrophic lateral sclerosis patient (Frontiers in cell and developmental biology · 2024
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Marc-André LécuyerNeuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada H2X 0A9.ORCID 0000-0003-0465-6122
Olivia Saint-LaurentNeuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada H2X 0A9.
Lyne BourbonnièreNeuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada H2X 0A9.
Sandra LaroucheNeuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada H2X 0A9.
Catherine LarochelleNeuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada H2X 0A9.
Laure MichelNeuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada H2X 0A9.
Marc CharabatiNeuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada H2X 0A9.
Michael AbadierTheodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.
Stephanie ZandeeNeuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada H2X 0A9.
Neda Haghayegh JahromiTheodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.
Elizabeth GowingNeuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada H2X 0A9.
Camille PittetNeuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada H2X 0A9.
Ruth LyckTheodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.
Britta EngelhardtTheodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.
Alexandre PratNeuroimmunology Research Laboratory, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada H2X 0A9; a.prat@umontreal.ca.ORCID 0000-0001-6188-0580
Centre Hospitalier de l’Université de Montréal · CAUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activated leukocyte cell adhesion molecule (ALCAM) is a cell adhesion molecule found on blood-brain barrier endothelial cells (BBB-ECs) that was previously shown to be involved in leukocyte transmigration across the endothelium. In the present study, we found that ALCAM knockout (KO) mice developed a more severe myelin oligodendrocyte glycoprotein (MOG)

Indexed as

Activated-Leukocyte Cell Adhesion MoleculeAnimalsBlood-Brain BarrierCells, CulturedEncephalomyelitis, Autoimmune, ExperimentalEndothelial CellsFemaleHomeostasisMice, Inbred C57BLMice, KnockoutMyelin-Oligodendrocyte GlycoproteinPeptide FragmentsSeverity of Illness IndexSpinal CordTight Junction ProteinsActivated-Leukocyte Cell Adhesion MoleculeMyelin-Oligodendrocyte Glycoproteinmyelin oligodendrocyte glycoprotein (35-55)Peptide FragmentsTight Junction ProteinsALCAMblood–brain barrierEAEmultiple sclerosistight junctions

Identifiers

PMID28069965
PMCPMC5278491
OpenAlexW2569166946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.