Evidence map›Paper›PMID 28069952›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Toxic PR

Kevin Y Shi, Eiichiro Mori, Zehra F Nizami, Yi Lin, Masato Kato, Siheng Xiang, Leeju C Wu, Ming Ding, Yonghao Yu, Joseph G Gall and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

149 citing papers in PubMed, 254 citations in OpenAlex.

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  8. Proceedings of the National Academy of Sciences of the United States of America · 2025
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  15. Identification of selective and non-selectiveMolecular therapy. Nucleic acids · 2024
    Article
  16. Advances in the understanding of nuclear pore complexes in human diseases.Journal of cancer research and clinical oncology · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article

89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kevin Y ShiDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Eiichiro MoriDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Zehra F NizamiDepartment of Embryology, Carnegie Institution for Science, Baltimore, MD 21218.
Yi LinDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Masato KatoDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Siheng XiangDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Leeju C WuDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Ming DingDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Yonghao YuDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Joseph G GallDepartment of Embryology, Carnegie Institution for Science, Baltimore, MD 21218.
Steven L McKnightDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 Steven.McKnight@UTSouthwestern.edu.
The University of Texas Southwestern Medical Center · USCarnegie Institution for Science · US

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Sandi Leigh Pruitt · 2010 to 2026
$53.7M
THE ORGANIZATION OF ANIMAL CELL NUCLEIR01GM033397 · NIGMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI GALL, JOSEPH G. · 1985 to 2019
$8.4M
Reversible Polymerization of Low Complexity Polypeptide Sequences as a FrameworkU01GM107623 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI MCKNIGHT, STEVEN L · 2014 to 2017
$2.0M
NCI NIH HHS P30 CA142543NIGMS NIH HHS R01 GM033397NIGMS NIH HHS U01 GM107623
6 · The paper itself

Abstract

The toxic proline:arginine (PR

Indexed as

Active Transport, Cell NucleusAnimalsBiopolymersC9orf72 ProteinDipeptidesDNA Repeat ExpansionFemaleGlycolsHumansMicroscopy, ConfocalNuclear PoreNuclear Pore Complex ProteinsOocytesPermeabilityProtein BindingProtein DomainsBiopolymersC9orf72 ProteinC9orf72 protein, humanDipeptidesGlycolshexamethylene glycolNuclear Pore Complex ProteinsNup98 protein, humanWheat Germ AgglutininsC9orf72 repeat expansionFG domainlabile cross-β polymersnuclear porePRn poly-dipeptide

Identifiers

PMID28069952
PMCPMC5320981
OpenAlexW2569387537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.