Evidence map›Paper›PMID 28069875›Full record

ArticleMolecular cancer therapeutics2017

15α-methoxypuupehenol Induces Antitumor Effects

Tyvette S Hilliard, Gabriella Miklossy, Christopher Chock, Peibin Yue, Philip Williams, James Turkson

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Roles of STAT3 in the pathogenesis and treatment of glioblastoma.Frontiers in cell and developmental biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tyvette S HilliardCancer Biology and Natural Products Program, University of Hawai'i Cancer Center, Honolulu, Hawaii.
Gabriella MiklossyCancer Biology and Natural Products Program, University of Hawai'i Cancer Center, Honolulu, Hawaii.
Christopher ChockDepartment of Chemistry, University of Hawai'i at Manoa, Honolulu, Hawaii.
Peibin YueCancer Biology and Natural Products Program, University of Hawai'i Cancer Center, Honolulu, Hawaii.
Philip WilliamsDepartment of Chemistry, University of Hawai'i at Manoa, Honolulu, Hawaii.
James TurksonCancer Biology and Natural Products Program, University of Hawai'i Cancer Center, Honolulu, Hawaii. jturkson@cc.hawaii.edu.
Cancer Center of Hawaii · USUniversity of Hawaiʻi at Mānoa · US

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
STAT3, G6PD and TrxR as underlying mechanisms for antitumor responses tohirsutinolidesR01CA208851 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI TURKSON, JAMES K · 2017 to 2021
$2.9M
Salicylic acid-based small-molecule Stat3 inhibitors for anticancer therapyR01CA161931 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI TURKSON, JAMES K · 2012 to 2016
$2.4M
Capture the Inhibitor: Affinity Approaches to the Discovery of Secretase LeadsR01AG039468 · NIA · UNIVERSITY OF HAWAII AT MANOA · PI WILLIAMS, PHILIP · 2011 to 2014
$1.1M
Therapeutic Application of Novel Stat3 Inhibitors in Breast and Pancreatic CancerR01CA128865 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI TURKSON, JAMES K · 2008 to 2011
$805k
NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA128865NCI NIH HHS R01 CA161931NCI NIH HHS R01 CA208851NIA NIH HHS R01 AG039468
6 · The paper itself

Abstract

Studies with 15α-methoxypuupehenol (15α-MP), obtained from the extracts of

Indexed as

AnimalsBrain NeoplasmsBreast NeoplasmsCaco-2 CellsCell Line, TumorCell ProliferationCell SurvivalCyclin B1FemaleGene Expression Regulation, NeoplasticGlioblastomaHumansMAP Kinase Signaling SystemMCF-7 CellsMiceSesquiterpenes15alpha-methoxypuupehenolCCNB1 protein, humanCyclin B1SesquiterpenesSTAT3 protein, humanSTAT3 Transcription Factor

Identifiers

PMID28069875
PMCPMC5380601
OpenAlexW2568185055

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.