Evidence map›Paper›PMID 28069828›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

LPA

Péter Tibor Dancs, Éva Ruisanchez, Andrea Balogh, Cecília Rita Panta, Zsuzsanna Miklós, Rolf M Nüsing, Junken Aoki, Jerold Chun, Stefan Offermanns, Gábor Tigyi and 1 more

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  4. Review
  5. Article
  6. Role of G-protein coupled receptors in cardiovascular diseases.Frontiers in cardiovascular medicine · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Lysophosphatidic acid acts on LPABritish journal of pharmacology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Péter Tibor DancsInstitute of Clinical Experimental Research, Semmelweis University, Budapest, Hungary.
Éva RuisanchezInstitute of Clinical Experimental Research, Semmelweis University, Budapest, Hungary.
Andrea BaloghDepartment of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Cecília Rita PantaInstitute of Clinical Experimental Research, Semmelweis University, Budapest, Hungary.
Zsuzsanna MiklósInstitute of Clinical Experimental Research, Semmelweis University, Budapest, Hungary.
Rolf M NüsingInstitute of Clinical Pharmacology, Goethe University, Frankfurt, Germany.
Junken AokiGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Jerold ChunSanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA; and.
Stefan OffermannsMax Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Gábor TigyiDepartment of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA; gtigyi@uthsc.edu.
Zoltán BenyóInstitute of Clinical Experimental Research, Semmelweis University, Budapest, Hungary; benyo.zoltan@med.semmelweis-univ.hu.
Semmelweis University · HUUniversity of Tennessee Health Science Center · USDiscovery Institute · USGoethe University Frankfurt · DEMax Planck Institute for Heart and Lung Research · DETohoku University · JP

Funding

Ligand Recognition by Phospholipid Growth Factor ReceptorsR01CA092160 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI TIGYI, GABOR J · 2001 to 2022
$5.9M
IND-Enabling Preclinical Development of a New RadiomitigatorU01AI107331 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI TIGYI, GABOR J · 2013 to 2018
$2.9M
Prenatal blood-borne lipids in post-hemorrhagic hydrocephalusR01NS084398 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI CHUN, JEROLD · 2014 to 2017
$2.6M
NCI NIH HHS R01 CA092160NIAID NIH HHS U01 AI107331NINDS NIH HHS R01 NS084398
6 · The paper itself

Abstract

Lysophosphatidic acid (LPA) has been recognized recently as an endothelium-dependent vasodilator, but several lines of evidence indicate that it may also stimulate vascular smooth muscle cells (VSMCs), thereby contributing to vasoregulation and remodeling. In the present study, mRNA expression of all 6 LPA receptor genes was detected in murine aortic VSMCs, with the highest levels of LPA

Indexed as

Muscle ContractionVasoconstrictionAnimalsAortaCyclooxygenase 1LysophospholipidsMaleMembrane ProteinsMiceMice, Inbred C57BLMuscle, Smooth, VascularReceptors, Lysophosphatidic AcidThromboxane A2Cyclooxygenase 1LysophospholipidsMembrane ProteinsPtgs1 protein, mouseReceptors, Lysophosphatidic AcidThromboxane A2endothelial dysfunctionLPAplatelet activationTP receptorvasoconstriction

Identifiers

PMID28069828
PMCPMC5349804
OpenAlexW2569318054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.