Evidence map›Paper›PMID 28069825›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B

Toshiaki Okuno, Sophia Koutsogiannaki, Mai Ohba, Matthew Chamberlain, Weiming Bu, Fu-Yan Lin, Roderic G Eckenhoff, Takehiko Yokomizo, Koichi Yuki

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Sedative choice altersInfection and immunity · 2026
    Article
  2. Review
  3. Article
  4. Propofol Protects Against Erastin-Induced Ferroptosis in HT-22 Cells.Journal of molecular neuroscience : MN · 2022
    Article
  5. Review
  6. The effect of anesthetics on toll like receptor 9.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  7. Review
  8. The role of propofol hydroxyl group in 5-lipoxygenase recognition.Biochemical and biophysical research communications · 2020
    Article
  9. Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  10. The volatile anesthetic sevoflurane reduces neutrophil apoptosisFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Toshiaki OkunoDepartment of Biochemistry, Juntendo University School of Medicine, Tokyo Japan.
Sophia KoutsogiannakiDivision of Cardiac Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston Massachusetts, USA.
Mai OhbaDepartment of Biochemistry, Juntendo University School of Medicine, Tokyo Japan.
Matthew ChamberlainDivision of Cardiac Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston Massachusetts, USA.
Weiming BuDepartment of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA; and.
Fu-Yan LinImmune Disease Institute, Boston Children's Hospital, Boston, Massachusetts, USA.
Roderic G EckenhoffDepartment of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA; and.
Takehiko YokomizoDepartment of Biochemistry, Juntendo University School of Medicine, Tokyo Japan.
Koichi YukiDivision of Cardiac Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston Massachusetts, USA; koichi.yuki@childrens.harvard.edu.
Juntendo University · JPBoston Children's Hospital · USUniversity of Pennsylvania · USCenter for Pain and the Brain · USHarvard University · US

Funding

X-ray and Neutron Interferometry Studies of Anesthetic Interactions with VoltageP01GM055876 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI COVARRUBIAS, MANUEL L · 1997 to 2017
$22.4M
The impact of anesthetic selection on sepsis outcome and its mechanismR01GM118277 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI YUKI, KOICHI · 2016 to 2020
$1.8M
Immunomodulatory mechanism of volatile anestheticsK08GM101345 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI YUKI, KOICHI · 2012 to 2016
$950k
NIGMS NIH HHS K08 GM101345NIGMS NIH HHS P01 GM055876NIGMS NIH HHS R01 GM118277
6 · The paper itself

Abstract

Propofol is an intravenous anesthetic that produces its anesthetic effect, largely

Indexed as

Anesthetics, IntravenousAnimalsArachidonate 5-LipoxygenaseArachidonic AcidsBinding SitesCells, CulturedHEK293 CellsHumansLeukotriene B4Lipoxygenase InhibitorsMaleMiceMice, Inbred C57BLNeutrophilsPropofolProtein BindingAnesthetics, IntravenousArachidonate 5-LipoxygenaseArachidonic AcidsLeukotriene B4Lipoxygenase InhibitorsPropofolanesthesiainhibitorlipid mediator

Identifiers

PMID28069825
PMCPMC5349797
OpenAlexW2569463693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.