Evidence map›Paper›PMID 28069818›Full record

ArticleInfection and immunity2017

SseK1 and SseK3 Type III Secretion System Effectors Inhibit NF-κB Signaling and Necroptotic Cell Death in Salmonella-Infected Macrophages.

Regina A Günster, Sophie A Matthews, David W Holden, Teresa L M Thurston

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. The Manipulation of Host Cells byInternational journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Mechanism of Bacterial ArginineACS catalysis · 2026
    Article
  9. Review
  10. Molecular strategies ofFrontiers in cellular and infection microbiology · 2026
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. The interplay betweenCell insight · 2025
    Review
  18. International journal of molecular sciences · 2025
    Review
  19. Article
  20. Infection biology ofEcoSal Plus · 2024
    Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Regina A GünsterSection of Microbiology, Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
Sophie A MatthewsSection of Microbiology, Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
David W HoldenSection of Microbiology, Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
Teresa L M ThurstonSection of Microbiology, Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom t.thurston@imperial.ac.uk.
Medical Research Council · GBImperial College London · GB

Funding

Medical Research Council MR/K027077/1Wellcome Trust 095484/Z/11/Z
6 · The paper itself

Abstract

Within host cells such as macrophages,

Indexed as

Signal TransductionType III Secretion SystemsAnimalsApoptosisArginineBacterial ProteinsCell DeathCell LineCells, CulturedGene Knockout TechniquesGlycosylationHeLa CellsHost-Pathogen InteractionsHumansMacrophagesMiceArginineBacterial ProteinsNF-kappa BSseK1 protein, Salmonella entericaTranscription FactorsTRIM32 protein, humanTripartite Motif ProteinsTumor Necrosis Factor-alphaType III Secretion SystemsUbiquitin-Protein Ligasescell deathnecroptosisNF-κB signalingSalmonella

Identifiers

PMID28069818
PMCPMC5328493
OpenAlexW2571548261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.