Evidence map›Paper›PMID 28069809›Full record

ArticleThe Journal of biological chemistry2017

The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels.

Amanda R Mason, Lisa P Elia, Steven Finkbeiner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Amanda R MasonGladstone Institute of Neurological Disease, San Francisco, California 94158; Taube/Koret Center for Neurodegenerative Disease Research, San Francisco, California 94158; Developmental and Stem Cell Biology Graduate Program; Medical Scientist Training Program.
Lisa P EliaGladstone Institute of Neurological Disease, San Francisco, California 94158; Taube/Koret Center for Neurodegenerative Disease Research, San Francisco, California 94158.
Steven FinkbeinerGladstone Institute of Neurological Disease, San Francisco, California 94158; Taube/Koret Center for Neurodegenerative Disease Research, San Francisco, California 94158; Departments of Physiology and Neurology, University of California, San Francisco, California 94158. Electronic address: sfinkbeiner@gladstone.ucsf.edu.
Taube Koret Center · USBiologie du Développement et Cellules Souches

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
PREDOCTORAL TRAINING IN DEVELOPMENTAL BIOLOGYT32HD007470 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 1994 to 2026
$7.7M
MECHANISMS OF HUNTINGTIN-INDUCED NEURODEGENERATIONR01NS039074 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI FINKBEINER, STEVEN M · 2000 to 2017
$5.4M
TRAP1 and FOXO1 as modifiers of progranulin and FTLDR21NS093236 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI FINKBEINER, STEVEN M · 2016 to 2017
$521k
NICHD NIH HHS T32 HD007470NIGMS NIH HHS T32 GM007618NINDS NIH HHS R01 NS039074NINDS NIH HHS R21 NS093236
6 · The paper itself

Abstract

Progranulin (PGRN), a secreted growth factor, is a key regulator of inflammation and is genetically linked to two common and devastating neurodegenerative diseases. Haploinsufficiency mutations in

Indexed as

Alzheimer DiseaseAnimalsCell LineCells, CulturedGranulinsIntercellular Signaling Peptides and ProteinsMiceNeuronsProgranulinsProtein BiosynthesisReceptor-Interacting Protein Serine-Threonine KinasesRNA InterferenceRNA, MessengerRNA, Small InterferingGranulinsGrn protein, mouseIntercellular Signaling Peptides and ProteinsProgranulinsReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouseRNA, MessengerRNA, Small InterferingAlzheimer diseasefrontotemporal dementianeurobiologyneurodegenerationneurodegenerative diseaseneurological diseaseprogranulinRipk1

Identifiers

PMID28069809
PMCPMC5336161
OpenAlexW2521373817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.