ArticleCancer research2017
Integrative Comparison of mRNA Expression Patterns in Breast Cancers from Caucasian and Asian Americans with Implications for Precision Medicine.
Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 23 citations in OpenAlex.
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- Multimerin 1 aids in the progression of ovarian cancer possibly via modulation of DNA damage response and repair pathways.Molecular and cellular biochemistry · 2023Article
- Concomitant analyses of intratumoral microbiota and genomic features reveal distinct racial differences in breast cancer.NPJ breast cancer · 2023Article
- Diagnostic and prognostic significance of SLC50A1 expression in patients with primary early breast cancer.Experimental and therapeutic medicine · 2022Article
- Efficacy and safety of nivolumab combined with brentuximab vedotin after nivolumab monotherapy failure in patients with relapsed and refractory classic Hodgkin lymphoma.International journal of clinical oncology · 2022Article
- Multimerin-1 and cancer: a review.Bioscience reports · 2022Review
- Cancer health disparities in racial/ethnic minorities in the United States.British journal of cancer · 2021Review
- Biological Network Inference With GRASP: A Bayesian Network Structure Learning Method Using Adaptive Sequential Monte Carlo.Frontiers in genetics · 2021Article
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- Identifying county-level factors for female breast cancer incidence rate through a large-scale population study.Applied geography (Sevenoaks, England) · 2020Article
- Triage of documents containing protein interactions affected by mutations using an NLP based machine learning approach.BMC genomics · 2020Article
- Maximizing the reusability of gene expression data by predicting missing metadata.PLoS computational biology · 2020Article
- Genetic factors associated with cancer racial disparity - an integrative study across twenty-one cancer types.Molecular oncology · 2020Article
- LncRNA LL22NC03-N14H11.1 promoted hepatocellular carcinoma progression through activating MAPK pathway to induce mitochondrial fission.Cell death & disease · 2020Article
- Transcriptomic characterization and innovative molecular classification of clear cell renal cell carcinoma in the Chinese population.Cancer cell international · 2020Article
- Study of Gene Expression Profiles of Breast Cancers in Indian Women.Scientific reports · 2019Article
- Extracting chemical-protein interactions from literature using sentence structure analysis and feature engineering.Database : the journal of biological databases and curation · 2019Article
- Profiling cytochrome P450 family 4 gene expression in human hepatocellular carcinoma.Molecular medicine reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Asian Americans (AS) have significantly lower incidence and mortality rates of breast cancer than Caucasian Americans (CA). Although this racial disparity has been documented, the underlying pathogenetic factors explaining it are obscure. We addressed this issue by an integrative genomics approach to compare mRNA expression between AS and CA cases of breast cancer. RNA-seq data from the Cancer Genome Atlas showed that mRNA expression revealed significant differences at gene and pathway levels. Increased susceptibility and severity in CA patients were likely the result of synergistic environmental and genetic risk factors, with arachidonic acid metabolism and PPAR signaling pathways implicated in linking environmental and genetic factors. An analysis that also added eQTL data from the Genotype-Tissue Expression Project and SNP data from the 1,000 Genomes Project identified several SNPs associated with differentially expressed genes. Overall, the associations we identified may enable a more focused study of genotypic differences that may help explain the disparity in breast cancer incidence and mortality rates in CA and AS populations and inform precision medicine. Cancer Res; 77(2); 423-33. ©2016 AACR.
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