Evidence map›Paper›PMID 28069704›Full record

ArticleCardiovascular research2017

Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes.

Takeshi Fujisawa, Keqing Wang, Xi-Lin Niu, Stuart Egginton, Shakil Ahmad, Peter Hewett, Christopher D Kontos, Asif Ahmed

Open access · bronzeAbstract read
In one paragraph

Article in Cardiovascular research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Takeshi FujisawaAston Medical Research Institute, Aston Medical School, Aston University, Birmingham B4 7ET, U.K.
Keqing WangAston Medical Research Institute, Aston Medical School, Aston University, Birmingham B4 7ET, U.K; asif.ahmed@aston.ac.uk k.wang@aston.ac.uk.
Xi-Lin NiuDepartment of Medicine, Division of Cardiology, Duke University Medical Centre, Durham, NC 27710, USA.
Stuart EggintonMultidisciplinary Cardiovascular Research Centre, School of Biological Sciences, University of Leeds, Leeds, UK.
Shakil AhmadAston Medical Research Institute, Aston Medical School, Aston University, Birmingham B4 7ET, U.K.
Peter HewettInstitute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Christopher D KontosDepartment of Medicine, Division of Cardiology, Duke University Medical Centre, Durham, NC 27710, USA.
Asif AhmedAston Medical Research Institute, Aston Medical School, Aston University, Birmingham B4 7ET, U.K; asif.ahmed@aston.ac.uk k.wang@aston.ac.uk.
University of Edinburgh · GBDuke Medical Center · USAston University · GBUniversity of Birmingham · GBUniversity of Leeds · GB

Funding

The Angiopoietins in Vascular Maintenance and RemodelingR01HL070165 · NHLBI · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 2002 to 2005
$1.4M
British Heart Foundation FS/15/72/31676British Heart Foundation RG/09/001/25940Medical Research Council G0601295Medical Research Council G0700288NHLBI NIH HHS R01 HL070165
6 · The paper itself

Abstract

aimsAtherosclerosis is a chronic inflammatory disease occurring within the artery wall. A crucial step in atherogenesis is the infiltration and retention of monocytes into the subendothelial space of large arteries induced by chemokines and growth factors. Angiopoietin-1 (Ang-1) regulates angiogenesis and reduces vascular permeability and has also been reported to promote monocyte migration in vitro. We investigated the role of Ang-1 in atherosclerosis-prone apolipoprotein-E (Apo-E) knockout mouse. METHODS AND

resultsApo-E knockout (Apo-E

conclusionsAng-1 specifically increases circulating Gr1

Indexed as

Plaque, AtheroscleroticAdenoviridaeAngiopoietin-1AnimalsAntigens, LyAorta, ThoracicAortic DiseasesApolipoproteins EAtherosclerosisCD11b AntigenChemokine CCL2Diet, High-FatDisease Models, AnimalGenetic Predisposition to DiseaseGenetic VectorsHumansAngiopoietin-1ANGPT1 protein, humanAntigens, LyApolipoproteins ECcl2 protein, mouseCD11b AntigenChemokine CCL2Ly6G antigen, mouseVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseAngiopoietin-1AtherosclerosisMonocytes

Identifiers

PMID28069704
PMCPMC5220674
OpenAlexW2550717258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.