Evidence map›Paper›PMID 28069641›Full record

ArticleDiabetes2017

Differential Impact of Chronic Hyperglycemia on Humoral Versus Cellular Primary Alloimmunity.

Nicholas H Bishop, Michelle K Nelsen, K Scott Beard, Marilyne Coulombe, Ronald G Gill

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicholas H BishopDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO.
Michelle K NelsenDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO.
K Scott BeardDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO.
Marilyne CoulombeDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO.
Ronald G GillDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO ronald.gill@ucdenver.edu.
University of Colorado Anschutz Medical Campus · US

Funding

Medical Scientist Training ProgramT32GM008497 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI WILSON, CARA C. · 1993 to 2022
$15.2M
TRAINING PROGRAM IN IMMUNOLOGYT32AI007405 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Laurel L Lenz, Raul Martin Torres · 1991 to 2026
$10.5M
Analysis of human autoreactive T cell receptors in vivoUC4DK104223 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI GILL, RONALD G · 2014 to 2014
$2.0M
Islet transplantation in autoimmune diabetesR01DK099187 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI GILL, RONALD G · 2014 to 2016
$912k
NIAID NIH HHS T32 AI007405NIDDK NIH HHS R01 DK099187NIDDK NIH HHS UC4 DK104223NIGMS NIH HHS T32 GM008497
6 · The paper itself

Abstract

Diabetes is prevalent among solid organ transplant recipients and is universal among islet transplant recipients. Whereas diabetes is often considered to result in an immune-compromised state, the impact of chronic hyperglycemia on host alloimmunity is not clear. Potential immune-modifying effects of obesity, autoimmunity, or diabetogenic agents like streptozotocin may confound understanding alloimmunity in experimental models of diabetes. Therefore, we sought to determine the role of chronic hyperglycemia due to insulinopenia on alloimmunity using the nonautoimmune, spontaneously diabetic H-2

Indexed as

AnimalsDiabetes MellitusGraft RejectionHyperglycemiaImmunity, CellularImmunity, HumoralInsulinIslets of Langerhans TransplantationMaleMiceMice, Inbred BALB CMice, Inbred C57BLMutationT-LymphocytesTransplantation, HomologousIns2 protein, mouseInsulin

Identifiers

PMID28069641
PMCPMC5360296
OpenAlexW2569621425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.