ArticleNeuroImage2017
Brain oscillations differentially encode noxious stimulus intensity and pain intensity.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03805854 (Modulating Pain Using Transcranial Alternating Stimulation), which is not on this map. Cited by 65 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modulating Pain Using Transcranial Alternating Stimulation (tACS) in Healthy Human Subjects
Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Variability and effect sizes of intracranial current source density estimations during pain: Systematic review, experimental findings, and future perspectives.Human brain mapping · 2021Pooled it
- Article
- Placebo and nocebo effects on pain through the lens of the predictive brain: Neurobiological mechanisms and translational implications.Experimental physiology · 2026Review
- EEG-based clustering shows distinct separation of chronic pain patients before spinal cord stimulation surgery.NeuroImage · 2026Article
- Toward a Predictive Coding Account of Hypnotic Hypoalgesia: Integrating EEG Oscillations and Somatosensory Evoked Responses.Brain sciences · 2026Review
- Predicting Pain: Electroencephalography Signatures of Neural Integration During Experimental Tonic Thermal Pain.European journal of pain (London, England) · 2026Article
- An exploratory study of headache pain intensity using facial expressions and APEX frames.NPJ digital medicine · 2026Article
- Transcranial alternating current stimulation (tACS) above individual peak alpha frequency (PAF) does not shift PAF or experimental pain sensitivity: an exploratory study.Frontiers in human neuroscience · 2026Article
- Bridging the Gap in Pain Measurement with a Brain-Based Index.International journal of environmental research and public health · 2025Article
- The effect of lateralization bias of pain on pain, anxiety and cognition in mice.Experimental brain research · 2025Article
- Objective monitoring of acute pain and nociception in anaesthesia and intensive care: evidence and applications.Anaesthesiology intensive therapy · 2025Review
- Classification accuracy of pain intensity induced by leg blood flow restriction during walking using machine learning based on electroencephalography.Scientific reports · 2025Article
- Preemptive transcranial direct current stimulation mitigates susceptibility to persistent pain.Communications biology · 2025Article
- Naturalistic acute pain states decoded from neural and facial dynamics.Nature communications · 2025Article
- EEG alpha/beta features as a biomarker for quantifying pain in patients with lumbar disk herniation.Frontiers in neuroscience · 2025Article
- Is there a difference between heat-capsaicin induced low back pain and placebo for neural oscillations and inflammatory blood markers? An experimental randomized crossover study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Nociception level index variations in ICU: curarized vs non-curarized patients - a pilot study.Journal of anesthesia, analgesia and critical care · 2024Article
- An Innovative EEG-Based Pain Identification and Quantification: A Pilot Study.Sensors (Basel, Switzerland) · 2024Article
- Targeting Prefrontal Cortex Dysfunction in Pain.The Journal of pharmacology and experimental therapeutics · 2024Review
- Evoked oscillatory cortical activity during acute pain: Probing brain in pain by transcranial magnetic stimulation combined with electroencephalogram.Human brain mapping · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Noxious stimuli induce physiological processes which commonly translate into pain. However, under certain conditions, pain intensity can substantially dissociate from stimulus intensity, e.g. during longer-lasting pain in chronic pain syndromes. How stimulus intensity and pain intensity are differentially represented in the human brain is, however, not yet fully understood. We therefore used electroencephalography (EEG) to investigate the cerebral representation of noxious stimulus intensity and pain intensity during 10min of painful heat stimulation in 39 healthy human participants. Time courses of objective stimulus intensity and subjective pain ratings indicated a dissociation of both measures. EEG data showed that stimulus intensity was encoded by decreases of neuronal oscillations at alpha and beta frequencies in sensorimotor areas. In contrast, pain intensity was encoded by gamma oscillations in the medial prefrontal cortex. Contrasting right versus left hand stimulation revealed that the encoding of stimulus intensity in contralateral sensorimotor areas depended on the stimulation side. In contrast, a conjunction analysis of right and left hand stimulation revealed that the encoding of pain in the medial prefrontal cortex was independent of the side of stimulation. Thus, the translation of noxious stimulus intensity into pain is associated with a change from a spatially specific representation of stimulus intensity by alpha and beta oscillations in sensorimotor areas to a spatially independent representation of pain by gamma oscillations in brain areas related to cognitive and affective-motivational processes. These findings extend the understanding of the brain mechanisms of nociception and pain and their dissociations during longer-lasting pain as a key symptom of chronic pain syndromes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.