ReviewToxicology in vitro : an international journal published in association with BIBRA2017
Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing.
Review in Toxicology in vitro : an international journal published in association with BIBRA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Enhancing toxicological interpretation and reporting ofFrontiers in toxicology · 2026Article
- QSAR Classification Modeling Using Machine Learning with a Consensus-Based Approach for Multivariate Chemical Hazard End Points.ACS omega · 2024Article
- Toxicological evaluation of microbial secondary metabolites in the context of European active substance approval for plant protection products.Environmental health : a global access science source · 2024Review
- Guidelines on Developmental Toxicity Tests: Brief Insights.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Proposing Effective Ecotoxicity Test Species for Chemical Safety Assessment in East Asia: A Review.Toxics · 2023Review
- International regulatory uses of acute systemic toxicity data and integration of new approach methodologies.Critical reviews in toxicology · 2023Review
- Principles and Procedures for Assessment of Acute Toxicity IncorporatingComputational toxicology (Amsterdam, Netherlands) · 2022Article
- Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data.Toxicology and applied pharmacology · 2022Article
- Fate of engineered nanomaterials at the human epithelial lung tissue barrierFrontiers in toxicology · 2022Article
- Assessment of RNA extraction protocols from cladocerans.PloS one · 2022Article
- Mapping Mechanistic Pathways of Acute Oral Systemic Toxicity Using Chemical Structure and Bioactivity Measurements.Frontiers in toxicology · 2022Article
- Performance of the GHS Mixtures Equation for Predicting Acute Oral Toxicity.Regulatory toxicology and pharmacology : RTP · 2021Article
- Myorelaxant Effect of theMolecules (Basel, Switzerland) · 2021Article
- A cross-industry collaboration to assess if acute oral toxicity (Q)SAR models are fit-for-purpose for GHS classification and labelling.Regulatory toxicology and pharmacology : RTP · 2021Article
- An integrated chemical environment with tools for chemical safety testing.Toxicology in vitro : an international journal published in association with BIBRA · 2020Article
- Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Harnessing the power of novel animal-free test methods for the development of COVID-19 drugs and vaccines.Archives of toxicology · 2020Article
- Use of LUCS (Light-Up Cell System) as an alternative live cell method to predict human acute oral toxicity.Toxicology reports · 2020Article
- An Overview ofBioMed research international · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Funding
Abstract
Acute systemic toxicity testing provides the basis for hazard labeling and risk management of chemicals. A number of international efforts have been directed at identifying non-animal alternatives for in vivo acute systemic toxicity tests. A September 2015 workshop, Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing, reviewed the state-of-the-science of non-animal alternatives for this testing and explored ways to facilitate implementation of alternatives. Workshop attendees included representatives from international regulatory agencies, academia, nongovernmental organizations, and industry. Resources identified as necessary for meaningful progress in implementing alternatives included compiling and making available high-quality reference data, training on use and interpretation of in vitro and in silico approaches, and global harmonization of testing requirements. Attendees particularly noted the need to characterize variability in reference data to evaluate new approaches. They also noted the importance of understanding the mechanisms of acute toxicity, which could be facilitated by the development of adverse outcome pathways. Workshop breakout groups explored different approaches to reducing or replacing animal use for acute toxicity testing, with each group crafting a roadmap and strategy to accomplish near-term progress. The workshop steering committee has organized efforts to implement the recommendations of the workshop participants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.