Trial reportThe Journal of allergy and clinical immunology2017
Race is associated with differences in airway inflammation in patients with asthma.
Trial report in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05246267 (Dupilumab Treatment Effects in an Ethnically Diverse Population With Chronic Rhinosinusitis With Nasal Polyposis), which is not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dupilumab Treatment Effects in an Ethnically Diverse Population With Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)
Who cites it
25 citing papers in PubMed.
- A randomized, placebo-controlled trial evaluating effects of lebrikizumab on airway eosinophilic inflammation and remodelling in uncontrolled asthma (CLAVIER).Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020Trial
- Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials.The Journal of allergy and clinical immunology · 2019Trial
- Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.The New England journal of medicine · 2019Trial
- Trial
- Article
- Upper Airway Volume Predicts Brain Structure and Cognition in Adolescents.American journal of respiratory and critical care medicine · 2025Article
- Asthma risk: the inseparable synergy of obesity and metabolism.BMC pulmonary medicine · 2025Article
- EndoPRS: Incorporating endophenotype information to improve polygenic risk scores for clinical endpoints-A study in asthma.American journal of human genetics · 2025Article
- Subtype prevalence and treatment implication in adolescents and adults with mild-to-moderate asthma: Systematic review and meta-analysis.The journal of allergy and clinical immunology. Global · 2025Article
- Recommendations for Clinicians to Combat Environmental Disparities in Pediatric Asthma: A Review.Chest · 2024Review
- Viral and non-viral episodes of wheezing in early life and the development of asthma and respiratory phenotypes among urban children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- The burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Project.The journal of allergy and clinical immunology. Global · 2024Article
- Asthma morbidity measures across Black ethnic subgroups.The Journal of allergy and clinical immunology · 2024Article
- Questions in Mild Asthma: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2023Article
- Genetic ancestry differences in pediatric asthma readmission are mediated by socioenvironmental factors.The Journal of allergy and clinical immunology · 2021Article
- An Overview of Health Disparities in Asthma.The Yale journal of biology and medicine · 2021Review
- Time to address ethnic inclusivity in children & young People's research.EClinicalMedicine · 2021Article
- Characteristics of inflammatory phenotypes among patients with asthma: relationships of blood count parameters with sputum cellular phenotypes.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021Article
- Disentangling the Coronavirus Disease 2019 Health Disparities in African Americans: Biological, Environmental, and Social Factors.Open forum infectious diseases · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Funding
Abstract
backgroundAfrican American subjects have a greater burden from asthma compared with white subjects. Whether the pattern of airway inflammation differs between African American and white subjects is unclear.
objectiveWe sought to compare sputum airway inflammatory phenotypes of African American and white subjects treated or not with inhaled corticosteroids (ICSs; ICS+ and ICS-, respectively).
methodsWe performed a secondary analysis of self-identified African American and white subjects with asthma enrolled in clinical trials conducted by the National Heart, Lung, and Blood Institute-sponsored Asthma Clinical Research Network and AsthmaNet. Demographics, clinical characteristics, and sputum cytology after sputum induction were examined. We used a sputum eosinophil 2% cut point to define subjects with either an eosinophilic (≥2%) or noneosinophilic (<2%) inflammatory phenotype.
resultsAmong 1018 participants, African American subjects (n = 264) had a lower FEV
conclusionAfrican American subjects exhibit greater eosinophilic airway inflammation, which might explain the greater asthma burden in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.