ArticleJournal of the International Neuropsychological Society : JINS2017
Cognitive Outcome in Childhood-Onset Epilepsy: A Five-Decade Prospective Cohort Study.
Article in Journal of the International Neuropsychological Society : JINS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Relationship of epilepsy on the linguistic-cognitive profile of children with ASD: A systematic review of the literature.Frontiers in psychology · 2023Pooled it
- Technical Neurosurgical Aspects of Pediatric Epilepsy Surgery Including Resections and Disconnections.Pediatric neurosurgery · 2026Review
- Exploring co-occurring conditions in Iraqi children with autism spectrum disorder: prevalence, characteristics, and potential risk factors.Frontiers in psychiatry · 2025Article
- Advancing precision diagnostics: minimally invasive approaches for understanding the role of brain-limited somatic mutations in pediatric drug-resistant epilepsy.Frontiers in surgery · 2025Review
- Predicting low cognitive ability at age 5 years using perinatal data and machine learning.Pediatric research · 2024Article
- General ability and specific cognitive functions are lower in children with epilepsy after perinatal ischemic stroke.Frontiers in stroke · 2024Article
- Prognostic factors for employment outcomes in patients with a history of childhood-onset drug-resistant epilepsy.Frontiers in pediatrics · 2023Article
- Brain language networks and cognitive outcomes in children with frontotemporal lobe epilepsy.Frontiers in human neuroscience · 2023Article
- Differences in brain changes between adults with childhood-onset epilepsy and controls: A prospective population-based study.Acta neurologica Scandinavica · 2022Article
- Behavioral characterization of dup15q syndrome: Toward meaningful endpoints for clinical trials.American journal of medical genetics. Part A · 2020Article
- Language Dysfunction in Pediatric Epilepsy.The Journal of pediatrics · 2018Review
- Brain structure and organization five decades after childhood onset epilepsy.Human brain mapping · 2017Article
- Association Between Childhood-Onset Epilepsy and Amyloid Burden 5 Decades Later.JAMA neurology · 2017Article
- Measuring the Barriers to Adherence With Neurology Clinic Appointments for Children With Epilepsy: A Pilot Study.Child neurology openArticle
- Social and Cognitive Outcome from Childhood-Onset Epilepsy: Do We Have Some Good News?Epilepsy currentsArticle
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesLittle is known about the very long-term cognitive outcome in patients with childhood-onset epilepsy. The aim of this unique prospective population-based cohort study was to examine cognitive outcomes in aging participants with childhood-onset epilepsy (mean onset age=5.3 years) five decades later (mean age at follow-up=56.5 years).
methodsThe sample consisted of 48 participants with childhood-onset epilepsy and 48 age-matched healthy controls aged 48-63 years. Thirty-six epilepsy participants were in remission and 12 continued to have seizures. Cognitive function was examined with 11 neuropsychological tests measuring language and semantic function, episodic memory, and learning, visuomotor function, executive function, and working memory.
resultsThe risk of cognitive impairment was very high in participants with continuing seizures; odds ratio (OR)=11.7 (95% confidence interval [CI] (2.8, 49.6), p=.0008). They exhibited worse performances across measures of language and semantic function, and visuomotor function compared to participants with remitted epilepsy and healthy controls. In the participants with remitted epilepsy, the risk of cognitive impairment was somewhat elevated, but not statistically significant; OR=2.6 (95% CI [0.9, 7.5], p=.08).
conclusionsOur results showed that the distinction of continued versus discontinued seizures was critical for determining long-term cognitive outcome in childhood-onset epilepsy. Few participants in remission exhibited marked cognitive impairment compared to age-matched peers. However, a subgroup of participants with decades long active epilepsy, continuous seizure activity and anti-epileptic drug (AED) medication, showed clinically significant cognitive impairment and are thus in a more precarious position when entering older age. (JINS, 2017, 23, 332-340).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.