ArticleBMC infectious diseases2017
Effectiveness of a serological tool to predict malaria transmission intensity in an elimination setting.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Optimizing age-structured sampling for estimating the seroconversion rate in malaria seroepidemiology: a simulation study.Scientific reports · 2026Article
- Serology reveals comparable patterns in the transmission intensities ofFrontiers in cellular and infection microbiology · 2025Article
- Using Serological Markers for the Surveillance ofPathogens (Basel, Switzerland) · 2023Article
- Serological surveillance on potentialFrontiers in cellular and infection microbiology · 2023Article
- Article
- The changing epidemiology of Plasmodium vivax: Insights from conventional and novel surveillance tools.PLoS medicine · 2021Review
- Antibody Profiles toThe American journal of tropical medicine and hygiene · 2020Article
- Seroprevalence and Parasite Rates ofThe American journal of tropical medicine and hygiene · 2020Article
- Comparison of Commercial ELISA Kits to Confirm the Absence of Transmission in Malaria Elimination Settings.Frontiers in public health · 2020Article
- Integrated Cross-Sectional Multiplex Serosurveillance of IgG Antibody Responses to Parasitic Diseases and Vaccines in Coastal Kenya.The American journal of tropical medicine and hygiene · 2020Article
- Causal Role of the Right Dorsolateral Prefrontal Cortex in Organizational Fairness Perception: Evidence From a Transcranial Direct Current Stimulation Study.Frontiers in behavioral neuroscience · 2020Article
- Mosquito Bite-Induced Controlled Human Malaria Infection with Plasmodium vivax or P. falciparum Generates Immune Responses to Homologous and Heterologous Preerythrocytic and Erythrocytic Antigens.Infection and immunity · 2019Article
- Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka.Malaria journal · 2018Article
- Estimating spatiotemporally varying malaria reproduction numbers in a near elimination setting.Nature communications · 2018Article
- Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon.Infectious diseases of poverty · 2018Article
- Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract.Malaria journal · 2017Article
- Chronic Exposure to Malaria Is Associated with Inhibitory and Activation Markers on Atypical Memory B Cells and Marginal Zone-Like B Cells.Frontiers in immunology · 2017Article
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7 authors.
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Abstract
backgroundSri Lanka achieved the WHO certificate as a malaria free country in September 2016, thus monitoring of malaria transmission using sensitive and effective tools is an important need. Use of age-specific antibody prevalence as a serological tool to predict transmission intensity is proven to be a cost effective and reliable method under elimination settings. This paper discusses the correlation of four anti-malarial antibodies against vivax and falciparum malaria with the declining transmission intensities in two previously high malaria endemic districts i.e. Kurunegala and Moneragala of Sri Lanka.
methodsSera was collected from 1,186 individuals from the two districts and were subjected to standard ELISA together with control sera from non-immune individuals to obtain Optical Density (OD) values for four anti-malarial antibodies i.e. anti-MSP1 and anti-AMA1 for both Plasmodium vivax and Plasmodium falciparum. The sero-positive samples were determined as mean OD + 3SD of the negative controls. The sero-prevalence was analyzed against the demographic characteristics of the population. A simple reversible catalytic model was fitted into sero-prevalence data to predict the sero-conversion and sero-reversion rates.
resultsOver 60% of the population was sero-positive for one or more antibodies except young children (<10 years). The sero-prevalence was zero in young children and very low in young adults when compared to the older age groups. The model developed for falciparum malaria that assumed the presence of a change in transmission was not significant in the Kurunegala district although significant reduction in transmission was observed when the model was used for P. vivax antibody data in that district. In Moneragala district however, all the serological markers indicated a change in transmission that has occurred approximately 15 years ago.
conclusionsAssessment of MSP1 and AMA1 anti-malarial antibodies of P. vivax and P. falciparum proved to be useful indicators in predicting transmission under elimination settings as prevailed in Sri Lanka. The sero-conversion rates for the two districts studied are shown to be very low or zero indicating the absence of active and/or hidden transmission confirming a "true" state of elimination at least, in the two study districts in Sri Lanka.
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