ArticleJournal of affective disorders2017
Temporal trends in antidepressant prescribing to children in UK primary care, 2000-2015.
Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prescription prevalence of psychotropic drugs in children and adolescents: an analysis of international data.European journal of clinical pharmacology · 2019Pooled it
- Population-Based Trends in Antidepressant Dispensing Among Children and Adolescents in Manitoba, Canada.Pharmacoepidemiology and drug safety · 2026Article
- Social deprivation in adolescence and risk of depression in young adulthood: a longitudinal analysis of linked administrative data from Northern Ireland.Social psychiatry and psychiatric epidemiology · 2026Article
- Predicting Suicide Attempt Trends in Youth: A Machine Learning Analysis Using Google Trends and Historical Data.Journal of clinical medicine · 2025Article
- Common mental disorders in young adults: temporal trends in primary care episodes and self-reported symptoms.BMJ mental health · 2025Article
- Replicability and reproducibility of predictive models for diagnosis of depression among young adults using Electronic Health Records.Diagnostic and prognostic research · 2023Article
- Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data.BMJ mental health · 2023Article
- Adolescent mental well-being, religion and family activities: a cross-sectional study (Northern Ireland Schools and Wellbeing Study).BMJ open · 2023Article
- Educational and health outcomes of schoolchildren in local authority care in Scotland: A retrospective record linkage study.PLoS medicine · 2021Article
- Psychotropic use in children and adolescents in Scandinavia and Catalonia: a 10-year population-based study.Psychopharmacology · 2021Article
- Temporal trends in annual incidence rates for psychiatric disorders and self-harm among children and adolescents in the UK, 2003-2018.BMC psychiatry · 2021Article
- Pharmacological Neuroenhancement: Current Aspects of Categorization, Epidemiology, Pharmacology, Drug Development, Ethics, and Future Perspectives.Neural plasticity · 2021Review
- Neurodevelopmental multimorbidity and educational outcomes of Scottish schoolchildren: A population-based record linkage cohort study.PLoS medicine · 2020Article
- Educational and health outcomes of children and adolescents receiving antidepressant medication: Scotland-wide retrospective record linkage cohort study of 766 237 schoolchildren.International journal of epidemiology · 2020Article
- Incidence and prevalence of primary care antidepressant prescribing in children and young people in England, 1998-2017: A population-based cohort study.PLoS medicine · 2020Article
- High-quality antidepressant prescribing: please consider whether "perfection is the enemy of progress".BMC medicine · 2020Article
- Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: a descriptive study using the QResearch database.BMC medicine · 2020Article
- Antidepressant Use During Development May Impair Women's Sexual Desire in Adulthood.The journal of sexual medicine · 2020Article
- Article
- Trends in antidepressant prescriptions in children and young people in England, 1998-2017: protocol of a cohort study using linked primary care and secondary care datasets.Evidence-based mental health · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe prevalence of antidepressant prescribing in children and adolescents increased steadily in the United States and parts of Europe between 2005 and 2012 despite regulatory safety warnings. Little is known about the characteristics of those being prescribed antidepressants for the first time.
methodsA longitudinal study of antidepressant prescribing in 3-17 year olds was carried out using data from the UK Clinical Practice Research Datalink (CPRD) between 2000 and 2015. Changes in the incidence of first ever antidepressant prescriptions and the characteristics of those being prescribed them was examined.
resultsIncidence of first ever prescriptions nearly doubled between 2006 and 2015 rising from 1.60 (95%CI: 1.51, 1.69) to 3.12 (3.00, 3.25) per 1000 person years. Only 21% of the 1721 patients with incident prescriptions in 2015 could be linked to a depression diagnosis, with an additional 22% of prescriptions linked to alternative indications. The incidence of prescriptions linked to a depression diagnosis increased between 2012 and 2015, with an adjusted incidence rate ratio of 1.46 (1.26, 1.70). Antidepressant prescribing for depression and other indications has been increasing most rapidly in 15 to 17 year old females. LIMITATIONS: Diagnoses are not directly linked to prescriptions in CPRD, so linkage must be inferred by temporal proximity.
conclusionsAntidepressant prescribing in children increased between 2006 and 2015. This is, at least in part, due to a rise in alternative uses of antidepressants, including the treatment of anxiety, chronic pain and migraines.
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