Evidence map›Paper›PMID 28068565›Full record

ArticleNeurobiology of aging2017

Retinal thinning is uniquely associated with medial temporal lobe atrophy in neurologically normal older adults.

Kaitlin B Casaletto, Michael E Ward, Nicholas S Baker, Brianne M Bettcher, Jeffrey M Gelfand, Yaqiao Li, Robert Chen, Shubir Dutt, Bruce Miller, Joel H Kramer and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Identification of Alzheimer's Disease by Imaging: A Comprehensive Review.International journal of environmental research and public health · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Schizophrenia in Translation: Why the Eye?Schizophrenia bulletin · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Kaitlin B CasalettoDepartment of Neurology, University of California, San Francisco, CA, USA. Electronic address: kaitlin.casaletto@ucsf.edu.
Michael E WardDepartment of Neurology, University of California, San Francisco, CA, USA; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Nicholas S BakerDepartment of Neurology, University of California, San Francisco, CA, USA.
Brianne M BettcherDepartment of Neurosurgery, Rocky Mountain Alzheimer's Disease Center, University of Colorado, Denver Anschutz Medical Center, Aurora, CO, USA; Department of Neurology, Rocky Mountain Alzheimer's Disease Center, University of Colorado, Denver Anschutz Medical Center, Auorora, CO, USA.
Jeffrey M GelfandDepartment of Neurology, University of California, San Francisco, CA, USA.
Yaqiao LiGladstone Institute of Neurological Disease, Department of Neurology, University of California, San Francisco, CA, USA.
Robert ChenDepartment of Neurology, University of California, San Francisco, CA, USA.
Shubir DuttDepartment of Neurology, University of California, San Francisco, CA, USA.
Bruce MillerDepartment of Neurology, University of California, San Francisco, CA, USA.
Joel H KramerDepartment of Neurology, University of California, San Francisco, CA, USA.
Ari J GreenDepartment of Neurology, University of California, San Francisco, CA, USA.
University of California, San Francisco · USGladstone Institutes · USNational Institute of Neurological Disorders and Stroke · USUniversity of Colorado Denver · US

Funding

PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Effects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2M
Cognitive and Neural Correlates of Inflammation in Healthy Older AdultsK23AG042492 · NIA · UNIVERSITY OF COLORADO DENVER · PI BETTCHER, BRIANNE MAGOUIRK · 2012 to 2016
$716k
A Metacognition-based Approach to Improve HAND Among Methamphetamine UsersF31DA035708 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CASALETTO, KAITLIN B · 2013 to 2015
$99k
NCATS NIH HHS KL2 TR000143NIA NIH HHS K23 AG042492NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG048234NIDA NIH HHS F31 DA035708
6 · The paper itself

Abstract

Given the converging pathologic and epidemiologic data indicating a relationship between retinal integrity and neurodegeneration, including Alzheimer's disease (AD), we aimed to determine if retinal structure correlates with medial temporal lobe (MTL) structure and function in neurologically normal older adults. Spectral-domain optical coherence tomography, verbal and visual memory testing, and 3T-magnetic resonance imaging of the brain were performed in 79 neurologically normal adults enrolled in a healthy aging cohort study. Retinal nerve fiber thinning and reduced total macular and macular ganglion cell volumes were each associated with smaller MTL volumes (ps < 0.04). Notably, these markers of retinal structure were not associated with primary motor cortex or basal ganglia volumes (regions relatively unaffected in AD) (ps > 0.70), or frontal, precuneus, or temporoparietal volumes (regions affected in later AD Braak staging ps > 0.20). Retinal structure was not significantly associated with verbal or visual memory consolidation performances (ps > 0.14). Retinal structure was associated with MTL volumes, but not memory performances, in otherwise neurologically normal older adults. Given that MTL atrophy is a neuropathological hallmark of AD, retinal integrity may be an early marker of ongoing AD-related brain health.

Indexed as

AgedAged, 80 and overAgingAlzheimer DiseaseAtrophyFemaleHumansMagnetic Resonance ImagingMaleNerve DegenerationRetinaTemporal LobeTomography, Optical CoherenceAgingAlzheimer's diseaseDementiaNeurodegenerative diseaseOptical coherence tomographyRetinal imaging

Identifiers

PMID28068565
PMCPMC5554591
OpenAlexW2562711545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.