ArticlePloS one2017
The Association between Foveal Morphology and Macular Pigment Spatial Distribution: An Ethnicity Study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- A novel computational model for human macular pigment optical density and its relationship to foveal structure.Scientific reports · 2025Article
- Advanced Analysis Tools for Two Wavelength Autofluorescence Imaging of Macular Xanthophyll Carotenoids: ALSTAR2 Baseline.Translational vision science & technology · 2025Observational
- Thinning of central foveal thickness in the retina of patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Revisiting NICE guidelines for initiation of intravitreal anti-VEGF therapy for centre-involving diabetic macular oedema: a survey of current interpretation in the United Kingdom.Eye (London, England) · 2022Article
- Foveal Curvature and Its Associations in UK Biobank Participants.Investigative ophthalmology & visual science · 2022Article
- Macular thickness varies with age-related macular degeneration genetic risk variants in the UK Biobank cohort.Scientific reports · 2021Article
- A Multitask Deep-Learning System to Classify Diabetic Macular Edema for Different Optical Coherence Tomography Devices: A Multicenter Analysis.Diabetes care · 2021Article
- Bardet-Biedl syndrome-7 (Ophthalmic genetics · 2021Article
- Foveal macular pigment dip in offspring of age-related macular degeneration patients is inversely associated with omega-3 index.BMC ophthalmology · 2020Article
- Local Abundance of Macular Xanthophyll Pigment Is Associated with Rod- and Cone-Mediated Vision in Aging and Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2020Article
- Spatial distribution of macular pigment estimated by autofluorescence imaging in elderly Japanese individuals.Japanese journal of ophthalmology · 2020Observational
- Objective method for measuring the macular pigment optical density in the eye.Biomedical optics express · 2019Article
- Investigating the potential of Zernike polynomials to characterise spatial distribution of macular pigment.PloS one · 2019Article
- Repeatability of the macular pigment spatial profile: A comparison of objective versus subjective classification.Acta ophthalmologica · 2018Article
- Interindividual Variations in Foveal Anatomy and Artifacts Seen on Inner Retinal Probability Maps from Spectral Domain OCT Scans of the Macula.Translational vision science & technology · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMacular pigment (MP) spatial distribution varies considerably among individuals. We investigated ethnic variations in MP spatial distribution in relation to foveal architecture.
methodsWe measured MP optical density (MPOD) using heterochromatic flicker photometry (MAP test, City, University of London) in 76 white, 80 South Asian and 70 black volunteers (18 to 39 years). MPOD spatial profiles were classified objectively as exponential, ring-like or central dip, based on deviations away from an exponential fit. Measurements including total retinal thickness (RT), inner retinal layer (IRL), inner and outer plexiform layer (IPL and OPL) thickness, foveal width and foveal pit slope were taken from Spectralis SD-OCT (Heidelberg, Germany) scans.
resultsIntegrated MPOD up to 1.8° (MPODint) was higher in South Asian (0.84±0.26) and black (0.84±0.31) than whites (0.63±0.24, P<0.0005). Ethnicity explained around 10% of the variance while gender played no significant role. MPOD profile phenotypes were associated with ethnicity: 58% with ring profiles were South Asian and 43% with dip profiles were black (χ2(4,226) = 13.4, P = 0.009). MPODint was lower in exponential (0.66±0.21) compared to ring-like (0.96±0.26) and central dip (1.00±0.32, P<0.0005) groups. White subjects had thicker IRL at 0° (130±21μm) than South Asian (123±16μm) and blacks (116±14μm; F(2) = 12.4, P<0.0005), with comparable results for IPL (P<0.0005) and OPL (P = 0.03). There was no significant difference in IRL, IPL or OPL (from 0 to 3.8° retinal eccentricity) or foveal width between MP profile groups (P>0.05).
conclusionWe report a significant difference in the amount and distribution of MP between ethnicities that is not explained by variations in foveal morphology.
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