ArticlePLoS genetics2017
Mutation Accumulation in an Asexual Relative of Arabidopsis.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
- The Use of dN/dS Ratios to Investigate Types of Selection in Related Sexual and Asexual Lineages.Genome biology and evolution · 2026Review
- Genomic consequences of residual recombination in a hybrid apomictic hickory complex.Nature communications · 2026Article
- Effects of mode of reproduction on genetic polymorphism and divergence in wild yams (Dioscoreaceae:Plant diversity · 2025Article
- Chromosome-level genome assemblies reveal genome evolution of an invasive plant Phragmites australis.Communications biology · 2024Article
- Relationships withinPlants (Basel, Switzerland) · 2024Article
- Apomixis and the paradox of sex in plants.Annals of botany · 2024Review
- Article
- Sex- versus apomixis-specific polymorphisms in the 5'UTR of APOLLO fromFrontiers in plant science · 2024Article
- The phenomenon of autonomous endosperm in sexual and apomictic plants.Journal of experimental botany · 2023Review
- Characterization of nuclear DNA diversity in an individualFrontiers in plant science · 2023Article
- Evolution of Transcriptomes in Early-Generation Hybrids of the ApomicticInternational journal of molecular sciences · 2022Article
- Evolution of an Apomixis-Specific Allele Class in Supernumerary Chromatin of ApomicticFrontiers in plant science · 2022Article
- Seed size, endosperm and germination variation in sexual and apomicticFrontiers in plant science · 2022Article
- Asexuality Associated with Marked Genomic Expansion of Tandemly Repeated rRNA and Histone Genes.Molecular biology and evolution · 2021Article
- Somatic variations led to the selection of acidic and acidless orange cultivars.Nature plants · 2021Article
- Fitness effects of spontaneous mutations in a warming world.Evolution; international journal of organic evolution · 2021Article
- Rapid local adaptation in both sexual and asexual invasive populations of monkeyflowers (Mimulus spp.).Annals of botany · 2021Article
- Identifying the fitness consequences of sex in complex natural environments.Evolution letters · 2020Article
- Chasing the Apomictic Factors in theGenes · 2020Article
- Gene Function Rather than Reproductive Mode Drives the Evolution of RNA Helicases in Sexual and Apomictic Boechera.Genome biology and evolution · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asexual populations experience weaker responses to natural selection, which causes deleterious mutations to accumulate over time. Additionally, stochastic loss of individuals free of deleterious mutations can lead to an irreversible increase in mutational load in asexuals (the "click" in Muller's Ratchet). Here we report on the genomic divergence and distribution of mutations across eight sympatric pairs of sexual and apomictic (asexual) Boechera (Brassicaceae) genotypes. We show that apomicts harbor a greater number of derived mutations than sympatric sexual genotypes. Furthermore, in phylogenetically constrained sites that are subject to contemporary purifying selection, the ancestral, conserved allele is more likely to be retained in sexuals than apomicts. These results indicate that apomictic lineages accumulate mutations at otherwise conserved sites more often than sexuals, and support the conclusion that deleterious mutation accumulation can be a powerful force in the evolution of asexual higher plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.