ArticleNature immunology2017
Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.
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Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
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Who cites it
59 citing papers in PubMed, 89 citations in OpenAlex.
- SPEN Loss Drives Extrafollicular Diffuse Large B-cell Lymphoma with Female-Specific Lethality and Therapeutic Vulnerabilities.Cancer discovery · 2026Article
- Quorum sensing underlies the establishment and maintenance of marginal zone B cells.bioRxiv : the preprint server for biology · 2026Article
- Activated PIK3CD drives marginal zone B cell development from early transitional progenitors by enhancing ADAM10 expression.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- B1 cells drive pulmonary emphysema progression through ADAM10.Respiratory research · 2026Article
- The Ste20 kinase TAOK3 restrains Rac-driven cytoskeletal-mitochondrial coupling to preserve naive CD8Frontiers in immunology · 2026Article
- The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases.Cell & bioscience · 2025Review
- Notch signalling in T cells: bridging tumour immunity and intratumoral cellular crosstalk.Frontiers in immunology · 2025Review
- The Marginal Zone B Cell Compartment and T Cell-independent Antibody Responses Are Supported by B Cell Intrinsic Expression of IRF1.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Tipping the Scale: Atheroprotective IgM-Producing B Cells in Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion.Nature communications · 2024Article
- Dynamic alterations in gene co-expression networks and gene-transcript associations characterize co-morbidities in cocaine use disorder.bioRxiv : the preprint server for biology · 2024Article
- Glycan-Reactive Innate-like B Cells and Developmental Checkpoints.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization.Nature communications · 2024Article
- Pleiotropic functions of TAO kinases and their dysregulation in neurological disorders.Science signaling · 2024Review
- Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function.Nature immunology · 2024Article
- Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice.Molecular medicine (Cambridge, Mass.) · 2023Article
- STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity.The Journal of experimental medicine · 2023Article
- TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα.Immunity & ageing : I & A · 2023Article
- Gene expression analysis of the Tao kinase family of Ste20p-like map kinase kinase kinases during early embryonic development in Xenopus laevis.Gene expression patterns : GEP · 2023Article
- GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity.Frontiers in immunology · 2023Article
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Authors and funding
18 authors at 7 institutions in 4 countries.
Hamida HammadVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
Matthias VanderkerkenVIB Inflammation Research Center, Ghent University, Ghent, Belgium.ORCID 0000-0002-0785-5904
Philippe PouliotVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
Kim DeswarteVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
Wendy ToussaintVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
Karl VergoteVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
Lana VandersarrenVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
Sophie JanssensVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
Ioanna RamouVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
Savvas N SavvidesVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
Jody J HaighVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
Rudi HendriksDepartment of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Manfred KopfInstitute for Molecular Health Sciences, ETH, Zürich, Switzerland.
Katleen CraessaertsVIB Center for Brain and Disease, VIB, Leuven, Belgium.
Bart de StrooperVIB Center for Brain and Disease, VIB, Leuven, Belgium.
John F KearneyDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Daniel H ConradCenter for Clinical and Translational Research, Virginia Commonwealth University, Richmond, Virginia, USA.
Bart N LambrechtVIB Inflammation Research Center, Ghent University, Ghent, Belgium.
Ghent University Hospital · BEGhent University · BEVIB-KU Leuven Center for Brain & Disease Research · BEErasmus MC · NLETH Zurich · CHUniversity of Alabama at Birmingham · USVirginia Commonwealth University · US
Funding
Regulation of B cell Clonal Diversity and Its Role in DiseaseR01AI014782 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEARNEY, JOHN FRANKLIN · 1985 to 2020
$7.1MEffects of neonatal microbial exposure on anti-polysaccharide B cell developmentR01AI100005 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEARNEY, JOHN FRANKLIN · 2012 to 2016
$1.8MMedical Research Council MC_PC_17116NIAID NIH HHS R01 AI014782NIAID NIH HHS R01 AI100005
Abstract
Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown how these pathways are related. We generated Taok3
Indexed as
Adaptive ImmunityCell DifferentiationCell LineageADAM10 ProteinAmyloid Precursor Protein SecretasesAnimalsB-LymphocytesCells, CulturedClonal Selection, Antigen-MediatedGene Expression RegulationGerminal CenterIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutADAM10 ProteinAdam10 protein, mouseAmyloid Precursor Protein SecretasesDll3 protein, mouseIntracellular Signaling Peptides and ProteinsMembrane ProteinsNotch2 protein, mouseProtein Serine-Threonine KinasesReceptor, Notch2Receptors, Antigen, B-CellTack3 kinase, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.