Evidence map›Paper›PMID 28067888›Full record

SynthesisBone marrow transplantation2017

Revisiting nutritional support for allogeneic hematologic stem cell transplantation-a systematic review.

A Baumgartner, A Bargetzi, N Zueger, M Bargetzi, M Medinger, L Bounoure, F Gomes, Z Stanga, B Mueller, P Schuetz

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Bone marrow transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 109 citations in OpenAlex.

  1. Vitamin requirements during stem cell transplantation: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Enteral versus parenteral nutrition in auto-HCT: a randomized controlled trial on clinical outcomes and gut microbiome dynamics.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  5. Trial
  6. A liberalized diet does not improve caloric intake during neutropenia in patients undergoing hematopoietic stem cell transplants: A prospective randomized controlled trial.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Trial
  7. Trial
  8. Trial
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Observational
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

A BaumgartnerAarau and Medical Faculty of the University of Basel, Division of Endocrinology/Metabolism/Clinical Nutrition, Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.
A BargetziAarau and Medical Faculty of the University of Basel, Division of Endocrinology/Metabolism/Clinical Nutrition, Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.
N ZuegerAarau and Medical Faculty of the University of Basel, Division of Endocrinology/Metabolism/Clinical Nutrition, Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.
M BargetziDivision of Oncology/Hematology and Transfusion Medicine, Kantonsspital Aarau, Aarau, Switzerland.
M MedingerDepartment of Hematology, University Hospital Basel, Basel, Switzerland.
L BounoureAarau and Medical Faculty of the University of Basel, Division of Endocrinology/Metabolism/Clinical Nutrition, Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.
F GomesAarau and Medical Faculty of the University of Basel, Division of Endocrinology/Metabolism/Clinical Nutrition, Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.
Z StangaDepartment of Endocrinology, Diabetes and Clinical Nutrition, Bern University Hospital, University of Bern, Switzerland.
B MuellerAarau and Medical Faculty of the University of Basel, Division of Endocrinology/Metabolism/Clinical Nutrition, Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.
P SchuetzAarau and Medical Faculty of the University of Basel, Division of Endocrinology/Metabolism/Clinical Nutrition, Medical University Department, Kantonsspital Aarau, Aarau, Switzerland.
Kantonsspital Aarau · CHUniversity Hospital of Basel · CHUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2009, the American Society of Parenteral and Enteral Nutrition and its European counterpart (Euopean Society for Parenteral and Enteral Nutrition) published guidelines regarding nutritional support of patients with hematologic stem cell transplantation. Our aim was to do an up-to-date literature review regarding benefit of nutritional interventions and treatment recommendations. We searched MEDLINE, EMBASE and Cochrane Library for interventional and observational clinical studies. We extracted data based on a predefined case report form and assessed bias. Out of 459 potential abstracts, 13 studies of mostly moderate quality with a total of 18 167 patients were included. Two very large trials reported negative associations of malnutrition and survival, transplant-related mortality and relapse risk. Some trials found enteral nutrition (EN) to be as effective as parenteral nutrition (PN) with lower complication rates. In addition, EN was associated with better survival, less acute GvHD and faster neutrophil recovery. A neutropenic diet was not superior regarding overall survival, but in contrast resulted in higher infection risk. Current moderate quality studies show negative associations of malnutrition and clinical outcomes, with EN being superior to PN. There was no benefit of neutropenic diets. Large, randomized controlled studies are needed to better understand optimal nutritional support in this patient population.

Indexed as

Hematopoietic Stem Cell TransplantationEnteral NutritionHumansMalnutritionNutritional SupportParenteral NutritionTreatment Outcome

Identifiers

PMID28067888
OpenAlexW2568356621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.