Evidence map›Paper›PMID 28067871›Full record

ArticleBone marrow transplantation2017

Tumor regression concomitant with steroid-refractory GvHD highlights the pitfalls of PD-1 blockade following allogeneic hematopoietic stem cell transplantation.

E McDuffee, G Aue, L Cook, C Ramos-Delgado, R Shalabi, T Worthy, P Vo, R W Childs

Abstract readCase Reports
In one paragraph

Article in Bone marrow transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Blockade of trans PD-L1 interaction with CD80 augments antitumor immunity.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Review
  5. Review
  6. Is There a Place for PD-1-PD-L Blockade in Acute Myeloid Leukemia?Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  7. Biology of Disease Relapse in Myeloid Disease: Implication for Strategies to Prevent and Treat Disease Relapse After Stem-Cell Transplantation.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

E McDuffeeDepartment of Hematology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
G AueDepartment of Hematology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
L CookDepartment of Hematology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
C Ramos-DelgadoDepartment of Hematology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
R ShalabiDepartment of Hematology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
T WorthyDepartment of Hematology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
P VoDepartment of Hematology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
R W ChildsDepartment of Hematology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Funding

Allogeneic Immunotherapy for cancer and nonmalignant hematological disordersZIAHL002345 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHILDS, RICHARD · 2009 to 2025
$53.3M
Cyclosporine Inhalation Solution (CIS) treatment of Bronchiolitis ObliteransZIAHL006090 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHILDS, RICHARD · 2010 to 2019
$3.9M
Intramural NIH HHS ZIA HL002345Intramural NIH HHS ZIA HL006090
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hematopoietic Stem Cell TransplantationAllograftsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedFemaleGraft vs Host DiseaseHodgkin DiseaseHumansNivolumabProgrammed Cell Death 1 ReceptorSteroidsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedNivolumabPDCD1 protein, humanpembrolizumabProgrammed Cell Death 1 ReceptorSteroids

Identifiers

PMID28067871
PMCPMC9069644

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.