ArticleScientific reports2017
Weak functional connectivity in the human fetal brain prior to preterm birth.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
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Who cites it
78 citing papers in PubMed, 156 citations in OpenAlex.
- Preterm Infants on Early Solid Foods and Neurodevelopmental Outcome-A Secondary Outcome Analysis of a Randomized Controlled Trial.Nutrients · 2024Trial
- An experimental test of the fetal programming hypothesis: Can we reduce child ontogenetic vulnerability to psychopathology by decreasing maternal depression?Development and psychopathology · 2018Trial
- Altered connectivity and network efficiency in preterm infants.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- The role of persistent inflammation in failed recovery after perinatal brain injury: is resolution the cure?Journal of neuroinflammation · 2026Review
- Utilizing functional neuroimaging to study early language development.Developmental cognitive neuroscience · 2025Review
- The overgrowth of structure-function coupling in premature brain during infancy.Developmental cognitive neuroscience · 2025Article
- Premature birth changes wiring constraints in neonatal structural brain networks.Nature communications · 2025Article
- Development of the basic architecture of neocortical circuitry in the human fetus as revealed by the coupling spatiotemporal pattern of synaptogenesis along with microstructure and macroscale in vivo MR imaging.Brain structure & function · 2024Article
- Longitudinal functional brain connectivity maturation in premature newborn infants: Modulatory influence of early music enrichment.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Functional connectivity of the pediatric brain.Neuroradiology · 2024Review
- Fetal and obstetrics manifestations of mitochondrial diseases.Journal of translational medicine · 2024Review
- Obstetrical and neonatal complications, prematurity, and childhood effortful control development: A longitudinal twin study.Developmental psychology · 2024Article
- Low-calorie diet-induced weight loss is associated with altered brain connectivity and food desire in obesity.Obesity (Silver Spring, Md.) · 2024Article
- Characterizing Large-Scale Human Circuit Development with In Vivo Neuroimaging.Cold Spring Harbor perspectives in biology · 2024Review
- Longitudinal MRI in the context of in utero surgery for open spina bifida: A descriptive study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Developmental trajectories of the default mode, frontoparietal, and salience networks from the third trimester through the newborn period.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Functional assessment of brain development in fetuses that subsequently deliver very preterm: An MRI pilot study.Prenatal diagnosis · 2024Article
- Fetal Frontolimbic Connectivity Prospectively Associates With Aggression in Toddlers.Biological psychiatry global open science · 2023Article
- Geodesic theory of long association fibers arrangement in the human fetal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Progressive inflammation reduces high-frequency EEG activity and cortical dendritic arborisation in late gestation fetal sheep.Journal of neuroinflammation · 2023Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
It has been suggested that neurological problems more frequent in those born preterm are expressed prior to birth, but owing to technical limitations, this has been difficult to test in humans. We applied novel fetal resting-state functional MRI to measure brain function in 32 human fetuses in utero and found that systems-level neural functional connectivity was diminished in fetuses that would subsequently be born preterm. Neural connectivity was reduced in a left-hemisphere pre-language region, and the degree to which connectivity of this left language region extended to right-hemisphere homologs was positively associated with the time elapsed between fMRI assessment and delivery. These results provide the first evidence that altered functional connectivity in the preterm brain is identifiable before birth. They suggest that neurodevelopmental disorders associated with preterm birth may result from neurological insults that begin in utero.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.