Evidence map›Paper›PMID 28067798›Full record

ArticleInternational journal of molecular sciences2017

Dark and Photoinduced Cytotoxic Activity of the New Chlorophyll-a Derivatives with Oligoethylene Glycol Substituents on the Periphery of Their Macrocycles.

Yana I Pylina, Dmitry M Shadrin, Oksana G Shevchenko, Olga M Startseva, Igor O Velegzhaninov, Dmitry V Belykh, Ilya O Velegzhaninov

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Photosensitizing effects and physicochemical properties of chlorophyll a derivatives with hydrophilic oligoethylene glycol fragments at the macrocycle periphery.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cytotoxic Compounds fromPharmacognosy research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yana I PylinaInstitute of Biology of Komi Science Centre of Ural Branch of RAS, Syktyvkar 167982, Russia. yanapylina@yandex.ru.
Dmitry M ShadrinInstitute of Biology of Komi Science Centre of Ural Branch of RAS, Syktyvkar 167982, Russia. shdimas@yandex.ru.
Oksana G ShevchenkoInstitute of Biology of Komi Science Centre of Ural Branch of RAS, Syktyvkar 167982, Russia. microtus69@mail.ru.
Olga M StartsevaInstitute of Chemistry of Komi Science Centre of Ural Branch of RAS, Syktyvkar 167982, Russia. om_smirnova@mail.ru.
Igor O VelegzhaninovInstitute of Geology of Komi Science Centre of Ural Branch of RAS, Syktyvkar 167982, Russia. saturn_vio@mail.ru.
Dmitry V BelykhInstitute of Chemistry of Komi Science Centre of Ural Branch of RAS, Syktyvkar 167982, Russia. belykh-dv@mail.ru.
Ilya O VelegzhaninovInstitute of Biology of Komi Science Centre of Ural Branch of RAS, Syktyvkar 167982, Russia. vellio@yandex.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present work, we investigated the dark and photoinduced cytotoxic activity of the new chlorophyll-a derivatives which contain the substituents of oligoethylene glycol on the periphery of their macrocycles. These compounds were tested using human cell lines to estimate their potential as photosensitizers for photodynamic therapy of cancer. It was shown that all the tested compounds have expressed photoinduced cytotoxic activity in vitro. Detailed study of the biological activity of one of the most perspective compound in this series-pyropheophorbide-a 17-diethylene glycol ester (Compound

Indexed as

A549 CellsAnimalsApoptosisCell LineCell SurvivalChlorophyllChlorophyllidesComet AssayDarknessDNA DamageDose-Response Relationship, DrugGene ExpressionHEK293 CellsHeLa CellsHemolysisHumansChlorophyllChlorophyllidesDH-I-180-3Photosensitizing AgentsphytochlorinPolyethylene GlycolsPorphyrinspyropheophorbide-a 17-diethylene glycol esterchlorophyll-a derivativescytotoxic activityHeLaoligoethylene glycol substituentphotodynamic therapyphotohemolysisphotosensitizer

Identifiers

PMID28067798
PMCPMC5297737

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.