ArticleBMJ open2016
Cohort profile: the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC).
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04676295 (Pre-eclampsia and Future Cardiovascular Health), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pre-eclampsia and Future Cardiovascular Health: An Underused Opportunity to Improve Family Health
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.Nature communications · 2020Pooled it
- Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.Nature genetics · 2017Pooled it
- Cardiac Structure and Function in 8- to 12-Year-Old Children Following In-Utero Exposure to Preeclampsia (FINNCARE Study).Journal of the American Heart Association · 2024Trial
- Observational
- Impact of Preeclampsia Duration on Long-Term Cardiovascular Disease Risk.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia.Annals of medicine · 2025Article
- Understanding rare genetic variants within the terminal pathway of complement system in preeclampsia.Genes and immunity · 2025Article
- The complement system in human pregnancy and preeclampsia.Frontiers in immunology · 2025Review
- A method for finding epistatic effects of maternal and fetal variants.Frontiers in genetics · 2025Article
- Impact of physical activity on preeclampsia and angiogenic markers in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort.Annals of medicine · 2024Article
- Fetal cord plasma herpesviruses and preeclampsia: an observational cohort study.Scientific reports · 2024Observational
- Rare variants in genes coding for components of the terminal pathway of the complement system in preeclampsia.Research square · 2024Article
- Machine learning-enabled maternal risk assessment for women with pre-eclampsia (the PIERS-ML model): a modelling study.The Lancet. Digital health · 2024Article
- Preeclampsia-exposed children's heart rate variability 8-12 yr after index pregnancy: FINNCARE study.American journal of physiology. Heart and circulatory physiology · 2024Article
- Identification of complement factor H variants that predispose to pre-eclampsia: A genetic and functional study.BJOG : an international journal of obstetrics and gynaecology · 2023Article
- Determinants of vascular structure and function in at-risk children born to mothers managed for pre-eclampsia (FINNCARE study).Frontiers in cardiovascular medicine · 2023Article
- Increased Risk of Preeclampsia in Women With a Genetic Predisposition to Elevated Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Protocol: A randomized controlled trial to assess effectiveness of a 12-month lifestyle intervention to reduce cardiovascular disease risk in families ten years after pre-eclampsia (FINNCARE).Preventive medicine reports · 2022Article
- Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia.Frontiers in immunology · 2022Article
- Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study.BJOG : an international journal of obstetrics and gynaecology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) Study was established to set up a nationwide clinical and DNA database on women with and without pre-eclampsia (PE), including their partners and infants, in order to identify genetic risk factors for PE.
participantsFINNPEC is a cross-sectional case-control cohort collected from 5 university hospitals in Finland during 2008-2011. A total of 1450 patients with PE and 1065 pregnant control women without PE (aged 18-47 years) were recruited. Altogether, there were 1377 full triads (625 PE and 752 control triads). FINDINGS TO DATE: The established cohort holds both clinical and genetic information of mother-infant-father triads representing a valuable resource for studying the pathogenesis of the disease. Furthermore, maternal biological samples (first and third trimester serum and placenta) will provide additional information for PE research. Until now, research has encompassed studies on candidate genes, Sanger and next-generation sequencing, and various studies on the placenta. FINNPEC has also participated in the InterPregGen study, which is the largest investigation on maternal and fetal genetic factors underlying PE until now. FUTURE PLANS: Ongoing studies focus on elucidating the role of immunogenetic and metabolic factors in PE. Data on morbidity and mortality will be collected from mothers and fathers through links to the nationwide health registers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.