ArticleeLife2017
Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.
Open access · goldAbstract readMulticenter Study
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
16.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency againsteLife · 2021Pooled it
- Prevalence, genetic variants and clinical implications of G-6-PD deficiency in Burkina Faso: a systematic review.BMC medical genetics · 2017Pooled it
- Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children.Malaria journal · 2023Trial
- High-throughput genotyping assays for identification of glycophorin B deletion variants in population studies.Experimental biology and medicine (Maywood, N.J.) · 2021Trial
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- Adaptive admixture at ACKR1, the Duffy blood group locus, may have shaped Plasmodium vivax prevalence in Oman.American journal of human genetics · 2026Article
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- Human genetic variations conferring resistance to malaria.Journal of translational medicine · 2025Review
- Relation Between the Dantu Blood Group Variant and Bacteremia in Kenyan Children: A Population-Based Case-Control Study.The Journal of infectious diseases · 2025Article
- Global, regional, and national burden of glucose-6-phosphate dehydrogenase (G6PD) deficiency from 1990 to 2021: a systematic analysis of the global burden of disease study 2021.Frontiers in genetics · 2025Article
- ApoE: A new piece to the severe malaria puzzle.Pediatric research · 2024Article
- The global role of G6PD in infection and immunity.Frontiers in immunology · 2024Review
- Severe Hemolysis during Primaquine Radical Cure of Plasmodium vivax Malaria: Two Systematic Reviews and Individual Patient Data Descriptive Analyses.The American journal of tropical medicine and hygiene · 2023Article
- Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria.PLoS genetics · 2023Article
- The Dantu blood group prevents parasite growtheLife · 2023Article
- Genome-wide association study identifies novel candidate malaria resistance genes in Cameroon.Human molecular genetics · 2023Article
- A world free of malaria: It is time for Africa to actively champion and take leadership of elimination and eradication strategies.African health sciences · 2022Article
- Revisiting the malaria hypothesis: accounting for polygenicity and pleiotropy.Trends in parasitology · 2022Review
- Impairment of Invasion and Maturation and Decreased Selectivity of Plasmodium falciparum in G6PD Viangchan and Mahidol Variants.The Journal of infectious diseases · 2022Article
- A robust method for collider bias correction in conditional genome-wide association studies.Nature communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
78 authors at 20 institutions in 18 countries.
Geraldine M ClarkeWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-7249-0289
Kirk RockettWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-6369-9299
Katja KivinenThe Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
Christina HubbartWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Anna E JeffreysWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Kate RowlandsWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Muminatou JallowMedical Research Council Unit The Gambia, Fajara, Gambia.
David J ConwayMedical Research Council Unit The Gambia, Fajara, Gambia.
Kalifa A BojangMedical Research Council Unit The Gambia, Fajara, Gambia.
Margaret PinderMedical Research Council Unit The Gambia, Fajara, Gambia.
Stanley UsenMedical Research Council Unit The Gambia, Fajara, Gambia.
Fatoumatta Sisay-JoofMedical Research Council Unit The Gambia, Fajara, Gambia.
Giorgio SirugoMedical Research Council Unit The Gambia, Fajara, Gambia.
Ousmane ToureMalaria Research and Training Centre, University of Bamako, Bamako, Mali.
Mahamadou A TheraMalaria Research and Training Centre, University of Bamako, Bamako, Mali.ORCID 0000-0002-2679-035X
Salimata KonateMalaria Research and Training Centre, University of Bamako, Bamako, Mali.
Sibiry SissokoMalaria Research and Training Centre, University of Bamako, Bamako, Mali.
Amadou NiangalyMalaria Research and Training Centre, University of Bamako, Bamako, Mali.
Belco PoudiougouMalaria Research and Training Centre, University of Bamako, Bamako, Mali.
Valentina D ManganoUniversity of Rome La Sapienza, Rome, Italy.
Edith C BougoumaCentre National de Recherche et de Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso.
Sodiomon B SirimaCentre National de Recherche et de Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso.
David ModianoUniversity of Rome La Sapienza, Rome, Italy.
Lucas N Amenga-EtegoNavrongo Health Research Centre, Navrongo, Ghana.
Anita GhansahNoguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Kwadwo A KoramNoguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Michael D WilsonNoguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Anthony EnimilKomfo Anoyke Teaching Hospital, Kumasi, Ghana.
Jennifer EvansDepartment of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Olukemi K AmoduUniversity of Ibadan, Ibadan, Nigeria.
Subulade OlaniyanUniversity of Ibadan, Ibadan, Nigeria.
Tobias ApinjohDepartment of Biochemistry and Molecular Biology, University of Buea, Buea, Cameroon.
Regina MugriDepartment of Medical Laboratory Sciences, University of Buea, Buea, Cameroon.
Andre NdiDepartment of Medical Laboratory Sciences, University of Buea, Buea, Cameroon.
Carolyne M NdilaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Sophie UyogaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Alexander MachariaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Norbert PeshuKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Thomas N WilliamsKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Alphaxard ManjuranoJoint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania.
Nuno SepúlvedaFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Taane G ClarkDepartment of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID 0000-0001-8985-9265
Eleanor RileyFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Chris DrakeleyJoint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania.
Hugh ReyburnJoint Malaria Programme, Kilimanjaro Christian Medical College, Moshi, Tanzania.
Vysaul NyirongoMalawi-Liverpool Wellcome Trust Clinical Research Programme, University of Malawi, Blantyre, Malawi.
David KachalaOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.
Malcolm MolyneuxMalawi-Liverpool Wellcome Trust Clinical Research Programme, University of Malawi, Blantyre, Malawi.
Sarah J DunstanThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.
Nguyen Hoan PhuOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.
Nguyen Ngoc QuyenOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.
Cao Quang ThaiOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.
Tran Tinh HienOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.
Laurens ManningPapua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Moses LamanPapua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Peter SibaPapua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Harin KarunajeewaUniversity of Western Australia, Perth, Australia.
Steve AllenSwansea University, Swansea, United Kingdom.
Angela AllenWeatherall Institute of Molecular Medicine, Oxford University, Oxford, United Kingdom.
Timothy Me DavisUniversity of Western Australia, Perth, Australia.
Pascal MichonPapua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Ivo MuellerPapua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Síle F MolloyWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Susana CampinoThe Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
Angeliki KerasidouWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Victoria J CorneliusWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Lee HartWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Shivang S ShahWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Gavin BandWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Chris Ca SpencerWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Tsiri AgbenyegaKomfo Anoyke Teaching Hospital, Kumasi, Ghana.
Eric AchidiDepartment of Medical Laboratory Sciences, University of Buea, Buea, Cameroon.
Ogobara K DoumboMalaria Research and Training Centre, University of Bamako, Bamako, Mali.
Jeremy FarrarOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.
Kevin MarshKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Terrie TaylorBlantyre Malaria Project at the College of Medicine, University of Malawi, Blantyre, Malawi.
Dominic P KwiatkowskiWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
MalariaGEN ConsortiumWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Centre for Human Genetics · GBOxford University Clinical Research Unit · VNUniversity of Bamako · MLKenya Medical Research Institute · KEMRC Unit the Gambia · GMUniversity of Buea · CMChristian Medical College, Vellore · INUniversity of Ghana · GHCentre National de Recherche et de Formation sur le Paludisme · BFKomfo Anokye Teaching Hospital · GHLondon School of Hygiene & Tropical Medicine · GBSapienza University of Rome · ITThe University of Western Australia · AUUniversity of Ibadan · NGUniversity of Liverpool · GBUniversity of London · GBUniversity of Oxford · GBWellcome Sanger Institute · GBDivine Word University · PGEdward Francis Small Teaching Hospital · GM
Funding
Medical Research Council G0600230Medical Research Council G0600718Medical Research Council G19/9Medical Research Council MC_UP_A900_1118Medical Research Council MR/M006212/1Wellcome Trust 084538Wellcome Trust 204911/Z/16/Z
Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed to confer protection against
Indexed as
AllelesAnemiaCase-Control StudiesGlucosephosphate DehydrogenaseGlucosephosphate Dehydrogenase DeficiencyHumansMalaria, CerebralMalaria, FalciparumRisk AssessmentGlucosephosphate Dehydrogenaseepidemiologyevolutionary biologyG6PD deficiencygenetic associationgenomicsglobal healthhumaninfectious diseaseselection
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.