ArticleLab on a chip2017
Automated 3D-printed unibody immunoarray for chemiluminescence detection of cancer biomarker proteins.
Article in Lab on a chip, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- 3D Bioprinting and Microfluidic-based Devices for Cancer Detection and Drug Treatment: Focus on Prostate Cancer.Current medicinal chemistry · 2026Review
- The promising applications of 3D printing technology for diagnosis and therapy of cancer: Recent advances and challenges.BioImpacts : BI · 2026Review
- Review
- 3D Printed Nanosensors for Cancer Diagnosis: Advances and Future Perspective.Current pharmaceutical design · 2024Review
- Microfluidics on lensless, semiconductor optical image sensors: challenges and opportunities for democratization of biosensing at the micro-and nano-scale.Nanophotonics (Berlin, Germany) · 2023Review
- Optical Detection of Cancer Cells Using Lab-on-a-Chip.Biosensors · 2023Review
- Conductive printable electrodes tuned by boron-doped nanodiamond foil additives for nitroexplosive detection.Mikrochimica acta · 2022Article
- High-Resolution 3D Printing Fabrication of a Microfluidic Platform for Blood Plasma Separation.Polymers · 2022Article
- Quantitative study for control of air-liquid segmented flow in a 3D-printed chip using a vacuum-driven system.Scientific reports · 2022Article
- Three-Dimensional (3D) Printing in Cancer Therapy and Diagnostics: Current Status and Future Perspectives.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Recent Advances in 3D Printing of Biomedical Sensing Devices.Advanced functional materials · 2022Article
- 3D Printed Personalized Medicine for Cancer: Applications for Betterment of Diagnosis, Prognosis and Treatment.AAPS PharmSciTech · 2021Review
- Multiplexed colorimetric detection of SARS-CoV-2 and other pathogens in wastewater on a 3D printed integrated microfluidic chip.Sensors and actuators. B, Chemical · 2021Article
- Multiplexed Prostate Cancer Companion Diagnostic Devices.Sensors (Basel, Switzerland) · 2021Review
- How 3D printing can boost advances in analytical and bioanalytical chemistry.Mikrochimica acta · 2021Review
- Biosensors Designed for Clinical Applications.Biomedicines · 2021Review
- Detecting cancer metastasis and accompanying protein biomarkers at single cell levels using a 3D-printed microfluidic immunoarray.Biosensors & bioelectronics · 2021Article
- 3D printed self-supporting elastomeric structures for multifunctional microfluidics.Science advances · 2020Article
- 3D-Printed Immunosensor Arrays for Cancer Diagnostics.Sensors (Basel, Switzerland) · 2020Review
- 3D Printed Microfluidics.Annual review of analytical chemistry (Palo Alto, Calif.) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
A low cost three-dimensional (3D) printed clear plastic microfluidic device was fabricated for fast, low cost automated protein detection. The unibody device features three reagent reservoirs, an efficient 3D network for passive mixing, and an optically transparent detection chamber housing a glass capture antibody array for measuring chemiluminescence output with a CCD camera. Sandwich type assays were built onto the glass arrays using a multi-labeled detection antibody-polyHRP (HRP = horseradish peroxidase). Total assay time was ∼30 min in a complete automated assay employing a programmable syringe pump so that the protocol required minimal operator intervention. The device was used for multiplexed detection of prostate cancer biomarker proteins prostate specific antigen (PSA) and platelet factor 4 (PF-4). Detection limits of 0.5 pg mL
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.