ArticleScientific reports2017
C. elegans-on-a-chip for in situ and in vivo Ag nanoparticles' uptake and toxicity assay.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- High-Throughput Toxicity Screening withEnvironmental science & technology · 2026Review
- HarnessingSensors (Basel, Switzerland) · 2025Review
- Recent Advances of PDMS In Vitro Biomodels for Flow Visualizations and Measurements: From Macro to Nanoscale Applications.Micromachines · 2024Review
- Review
- Nanoparticles-induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models.MedComm · 2023Review
- Review
- Daphnia as a model organism to probe biological responses to nanomaterials-from individual to population effects via adverse outcome pathways.Frontiers in toxicology · 2023Review
- Article
- Deficiency in RCAT-1 Function Causes Dopamine Metabolism Related Behavioral Disorders inInternational journal of molecular sciences · 2022Article
- Citric Acid-Mediated Microwave-Hydrothermal Synthesis of Mesoporous F-Doped HAp Nanorods from Bio-Waste for Biocidal Implant Applications.Nanomaterials (Basel, Switzerland) · 2022Article
- Silver nanoparticles enhance the efficacy of aminoglycosides against antibiotic-resistant bacteria.Frontiers in microbiology · 2022Article
- A Review on Conventional and Advanced Methods for Nanotoxicology Evaluation of Engineered Nanomaterials.Molecules (Basel, Switzerland) · 2021Review
- The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies.International journal of molecular sciences · 2020Review
- Silver nanoparticles: Synthesis, medical applications and biosafety.Theranostics · 2020Review
- State-of-Art Bio-Assay Systems and Electrochemical Approaches for Nanotoxicity Assessment.Frontiers in bioengineering and biotechnology · 2020Review
- Microfluidic Technologies for High Throughput Screening Through Sorting and On-Chip Culture ofMolecules (Basel, Switzerland) · 2019Review
- Evaluating Nanoparticles in Preclinical Research Using Microfluidic Systems.Micromachines · 2019Review
- Materials and toxicological approaches to study metal and metal-oxide nanoparticles in the model organismMaterials horizons · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanomaterials are extensively used in consumer products and medical applications, but little is known about their environmental and biological toxicities. Moreover, the toxicity analysis requires sophisticated instruments and labor-intensive experiments. Here we report a microfluidic chip incorporated with the nematode Caenorhabditis elegans that rapidly displays the changes in body growth and gene expression specifically responsive to the silver nanoparticles (AgNPs). C. elegans were cultured in microfluidic chambers in the presence or absence of AgNPs and were consequently transferred to wedge-shaped channels, which immobilized the animals, allowing the evaluation of parameters such as length, moving distance, and fluorescence from the reporter gene. The AgNPs reduced the length of C. elegans body, which was easily identified in the channel of chip. In addition, the decrease of body width enabled the worm to advance the longer distance compared to the animal without nanoparticles in a wedge-shaped channel. The transgenic marker DNA, mtl-2::gfp was highly expressed upon the uptake of AgNPs, resulting in green fluorescence emission. The comparative investigation using gold nanoparticles and heavy-metal ions indicated that these parameters are specific to AgNPs. These results demonstrate that C. elegans-on-a-chip has a great potential as a rapid and specific nanoparticle detection or nanotoxicity assessment system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.