ArticleScientific reports2017
Long-term exposure to a 'safe' dose of bisphenol A reduced protein acetylation in adult rat testes.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 71 citations in OpenAlex.
- Transgenerational reproductive risks of BPA: epigenetic mechanisms and biomarker applications. A critical review.Environmental epigenetics · 2026Review
- Induction of Phosphorylated Tau Accumulation and Memory Impairment by Bisphenol A and the Protective Effects of Carnosic Acid in In Vitro and In Vivo.Molecular neurobiology · 2024Article
- White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming.Pharmaceuticals (Basel, Switzerland) · 2024Review
- An Overview to Molecularly Imprinted Electrochemical Sensors for the Detection of Bisphenol A.Sensors (Basel, Switzerland) · 2023Review
- Unraveling Obesity: Transgenerational Inheritance, Treatment Side Effects, Flavonoids, Mechanisms, Microbiota, Redox Balance, and Bioavailability-A Narrative Review.Antioxidants (Basel, Switzerland) · 2023Review
- The State of Research and Weight of Evidence on the Epigenetic Effects of Bisphenol A.International journal of molecular sciences · 2023Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro data.Clinical epigenetics · 2022Article
- Developmental origins of adult diseases.Medical review (2021) · 2022Review
- Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study.International journal of molecular sciences · 2022Review
- Environmental Impact on Male (In)Fertility via Epigenetic Route.Journal of clinical medicine · 2020Review
- Untangling the association between environmental endocrine disruptive chemicals and the etiology of male genitourinary cancers.Biochemical pharmacology · 2020Review
- Oxidative Stress and DNA methylation in male rat pups provoked by the transplacental and translactational exposure to bisphenol A.Environmental science and pollution research international · 2020Article
- Bisphenol A-Induced Epigenetic Changes and Its Effects on the Male Reproductive System.Frontiers in endocrinology · 2020Review
- Bisphenols Threaten Male Reproductive Health via Testicular Cells.Frontiers in endocrinology · 2020Review
- Genetic and epigenetic alterations induced by bisphenol A exposure during different periods of spermatogenesis: from spermatozoa to the progeny.Scientific reports · 2019Article
- Embryonic Exposure to Bisphenol A Impairs Primordial Germ Cell Migration without Jeopardizing Male Breeding Capacity.Biomolecules · 2019Article
- Neuro-toxic and Reproductive Effects of BPA.Current neuropharmacology · 2019Review
- Effects of bisphenol A and its analogs on reproductive health: A mini review.Reproductive toxicology (Elmsford, N.Y.) · 2018Review
- Camptothecin Efficacy to Poison Top1 Is Altered by Bisphenol A in Mouse Embryonic Fibroblasts.Chemical research in toxicology · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bisphenol A (BPA), a typical environmental endocrine-disrupting chemical, induces epigenetic inheritance. Whether histone acetylation plays a role in these effects of BPA is largely unknown. Here, we investigated histone acetylation in male rats after long-term exposure to a 'safe' dose of BPA. Twenty adult male rats received either BPA (50 μg/kg·bw/day) or a vehicle diet for 35 weeks. Decreased protein lysine-acetylation levels at approximately ~17 kDa and ~25 kDa, as well as decreased histone acetylation of H3K9, H3K27 and H4K12, were detected by Western blot analysis of testes from the treated rats compared with controls. Additionally, increased protein expression of deacetylase Sirt1 and reduced binding of Sirt1, together with increased binding of estrogen receptor β (ERβ) to caveolin-1 (Cav-1), a structural protein component of caveolar membranes, were detected in treated rats compared with controls. Moreover, decreased acetylation of Cav-1 was observed in the treated rats for the first time. Our study showed that long-term exposure to a 'safe' dose of BPA reduces histone acetylation in the male reproductive system, which may be related to the phenotypic paternal-to-offspring transmission observed in our previous study. The evidence also suggested that these epigenetic effects may be meditated by Sirt1 via competition with ERβ for binding to Cav-1.
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