ArticleScientific reports2017
Cumulative Resting Heart Rate Exposure and Risk of All-Cause Mortality: Results from the Kailuan Cohort Study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relationship Between Heart Rate and Mortality Risk in Patients With Acute Aortic Dissection: A Meta-Analysis.Reviews in cardiovascular medicine · 2025Pooled it
- Association of resting heart rate trajectories with incident chronic kidney disease in patients with hypertension.Clinical hypertension · 2026Article
- Association of cumulative resting heart rate exposure with rapid renal function decline: a prospective cohort study with 27,564 older adults.Journal of geriatric cardiology : JGC · 2023Article
- Effect of Heart Rate on 1-Year Outcome for Patients With Acute Ischemic Stroke.Journal of the American Heart Association · 2022Article
- Time course of serum uric acid accumulation and the risk of diabetes mellitus.Nutrition & diabetes · 2022Article
- Association between cumulative exposure to different lipid parameters and risk of newly developed carotid plaque.Stroke and vascular neurology · 2021Article
- Cumulative Serum Uric Acid and Its Time Course Are Associated With Risk of Myocardial Infarction and All-Cause Mortality.Journal of the American Heart Association · 2021Observational
- Admission Resting Heart Rate as an Independent Predictor of All-Cause Mortality in Elderly Patients with Hip Fracture.International journal of general medicine · 2021Article
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12 authors.
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Abstract
The relationship between cumulative exposure to resting heart rate (cumRHR) and mortality remain unclear in the general population. In the Kailuan cohort study, resting heart rate (RHR) was repeatedly measured at baseline and at years 2 and 4 by electrocardiogram among 47,311 adults aged 48.70 ± 11.68. The cumRHR was defined as the summed average RHR between two consecutive examinations multiplied by the time interval between with two examinations [(beats/min) * year]. A higher RHR was defined as ≥80 beats/min, and the number of visits with a higher RHR was counted. During a median of 4.06 years of follow-up, a total of 1,025 participants died. After adjusting for major traditional cardiovascular risk factors and baseline RHR, the hazard ratio for the highest versus lowest quartile of cumRHR was 1.39 (95% CI: 1.07-1.81) for all-cause mortality. Each 1-SD increment in cumRHR was associated with a 37% (HR: 1.37, 95% CI: 1.23-1.52) increased risk of death and displayed a J-shaped relationship. Compared with no exposure, adults who had a higher RHR at all 3 study visits were associated with a 1.86-fold higher risk (95% CI: 1.33-2.61) of mortality. In summary, cumulative exposure to higher RHR is independently associated with an increased risk of mortality.
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