Evidence map›Paper›PMID 28067307›Full record

ArticleScientific reports2017

Fluorescent Gold Nanoclusters for Selective Detection of Dopamine in Cerebrospinal fluid.

Saravanan Govindaraju, Seshadri Reddy Ankireddy, Buddolla Viswanath, Jongsung Kim, Kyusik Yun

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 242 citations in OpenAlex.

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  16. The Atomically Precise Gold/Captopril Nanocluster AuACS applied materials & interfaces · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Saravanan GovindarajuDepartment of Bionanotechnology, Gachon University, Gyeonggi-do, 13120, Republic of Korea.
Seshadri Reddy AnkireddyDepartment of Chemical and Biological Engineering, Gachon University, Gyeonggi-do, 13120, Republic of Korea.
Buddolla ViswanathDepartment of Bionanotechnology, Gachon University, Gyeonggi-do, 13120, Republic of Korea.
Jongsung KimDepartment of Chemical and Biological Engineering, Gachon University, Gyeonggi-do, 13120, Republic of Korea.
Kyusik YunDepartment of Bionanotechnology, Gachon University, Gyeonggi-do, 13120, Republic of Korea.
Gachon University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the last two decades, protein conjugated fluorescent gold nanoclusters (NCs) owe much attention in the field of medical and nanobiotechnology due to their excellent photo stability characteristics. In this paper, we reported stable, nontoxic and red fluorescent emission BSA-Au NCs for selective detection of L-dopamine (DA) in cerebrospinal fluid (CSF). The evolution was probed by various instrumental techniques such as UV-vis spectroscopy, High resolution transmission electron microscopy (HTEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), photoluminescence spectroscopy (PL). The synthesised BSA-Au NCs were showing 4-6 nm with high fluorescent ~8% Quantum yield (QY). The fluorescence intensity of BSA-Au NCs was quenched upon the addition of various concentrations of DA via an electron transfer mechanism. The decrease in BSA-Au NCs fluorescence intensity made it possible to determine DA in PBS buffer and the spiked DA in CSF in the linear range from 0 to 10 nM with the limit of detection (LOD) 0.622 and 0.830 nM respectively. Best of our knowledge, as-prepared BSA-Au NCs will gain possible strategy and good platform for biosensor, drug discovery, and rapid disease diagnosis such as Parkinson's and Alzheimer diseases.

Indexed as

DopamineFluorescenceGoldMetal NanoparticlesPhotoelectron SpectroscopySerum Albumin, BovineSpectrophotometry, UltravioletSpectroscopy, Fourier Transform InfraredTime FactorsX-Ray DiffractionDopamineGoldSerum Albumin, Bovine

Identifiers

PMID28067307
PMCPMC5220289
OpenAlexW2568998604

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.