Evidence map›Paper›PMID 28067240›Full record

ArticleNature communications2017

CD8

Yunmeng Liu, Tonya M Rafferty, Sung W Rhee, Jessica S Webber, Li Song, Benjamin Ko, Robert S Hoover, Beixiang He, Shengyu Mu

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 92 citations in OpenAlex.

  1. Salt and chronic kidney disease.Nature reviews. Nephrology · 2026
    Review
  2. Spatial Atlas Creation at the Single Cell Level: Unveiling the Human Kidney Metaverse.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Recent advances on immunity and hypertension: the new cells on the kidney block.American journal of physiology. Renal physiology · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Immune Mechanisms in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2024
    Review
  16. Review
  17. Article
  18. Review
  19. Hypertension (Dallas, Tex. : 1979) · 2024
    Article
  20. Immune cells and hypertension.Immunologic research · 2024
    Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yunmeng LiuDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Tonya M RaffertyDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Sung W RheeDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Jessica S WebberDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Li SongDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Benjamin KoDepartment of Medicine, University of Chicago, Chicago, Illinois 60637, USA.
Robert S HooverDepartment of Medicine, Division of Nephrology, Emory University, Atlanta, Georgia 30322, USA.
Beixiang HeDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Shengyu MuDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
University of Arkansas for Medical Sciences · USEmory University · USUniversity of Chicago · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI ABADIE, VALERIE · 1990 to 2025
$29.8M
PSD95 scaffolding of vascular K+ channels in hypertensionR01HL097107 · NHLBI · UNIV OF ARKANSAS FOR MED SCIS · PI RHEE, SUNG W · 2010 to 2014
$1.8M
Mechanisms of Hormonal Regulation of the Sodium Chloride CotransporterR01DK085097 · NIDDK · EMORY UNIVERSITY · PI HOOVER, ROBERT S · 2010 to 2015
$1.5M
Super-Resolution Light Microscope at University of Arkansas for Medical SciencesS10OD018065 · OD · UNIV OF ARKANSAS FOR MED SCIS · PI STORRIE, BRIAN · 2015 to 2015
$600k
NCC and ENaC form a Sodium Transporting ComplexI01BX002322 · VA · VETERANS HEALTH ADMINISTRATION · PI HOOVER, ROBERT S · 2016 to 2020
–
BLRD VA I01 BX002322NHLBI NIH HHS R01 HL097107NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK085097NIH HHS S10 OD018065
6 · The paper itself

Abstract

Recent studies suggest a role for T lymphocytes in hypertension. However, whether T cells contribute to renal sodium retention and salt-sensitive hypertension is unknown. Here we demonstrate that T cells infiltrate into the kidney of salt-sensitive hypertensive animals. In particular, CD8

Indexed as

Adoptive TransferAnimalsCD8-Positive T-LymphocytesChloride ChannelsChloridesCoculture TechniquesDeoxycholic AcidEpithelial CellsGene Expression RegulationHypertensionIon TransportKcnj10 ChannelKidney Tubules, DistalMaleMiceMice, Inbred C57BLChloride ChannelsChloridesClcnka protein, mouseDeoxycholic AcidKcnj10 ChannelPotassium Channels, Inwardly RectifyingReactive Oxygen SpeciesSlc12a3 protein, mouseSodiumSolute Carrier Family 12, Member 3src-Family Kinases

Identifiers

PMID28067240
PMCPMC5227995
OpenAlexW2570185708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.