ArticleNature communications2017
Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- A Selective Cortico-Limbic Network Organizes Behavior During Reward Seeking Under Threat.Journal of neuroscience research · 2026Article
- Cortical Granularity Shapes the Organization of Afferent Paths to the Amygdala and Its Striatal Targets in Nonhuman Primate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Temporal prediction error triggers amygdala-dependent memory updating in appetitive operant conditioning in rats.Frontiers in behavioral neuroscience · 2022Article
- Ramping activity in the striatum.Frontiers in computational neuroscience · 2022Article
- The dorsal hippocampus is required for the formation of long-term duration memories in rats.The European journal of neuroscience · 2021Article
- Timing behavior in genetic murine models of neurological and psychiatric diseases.Experimental brain research · 2021Review
- Asymmetry in updating long-term memory for time.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Respiration and brain neural dynamics associated with interval timing during odor fear learning in rats.Scientific reports · 2020Article
- Temporal Learning Among Prefrontal and Striatal Ensembles.Cerebral cortex communications · 2020Article
- Internal Clocks, mGluR7 and Microtubules: A Primer for the Molecular Encoding of Target Durations in Cerebellar Purkinje Cells and Striatal Medium Spiny Neurons.Frontiers in molecular neuroscience · 2019Article
- Network Brain-Computer Interface (nBCI): An Alternative Approach for Cognitive Prosthetics.Frontiers in neuroscience · 2018Article
- Inactivation of the Medial-Prefrontal Cortex Impairs Interval Timing Precision, but Not Timing Accuracy or Scalar Timing in a Peak-Interval Procedure in Rats.Frontiers in integrative neuroscience · 2018Article
- Biological and Cognitive Frameworks for a Mental Timeline.Frontiers in neuroscience · 2018Article
- Non-linear auto-regressive models for cross-frequency coupling in neural time series.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 3 countries.
Funding
Abstract
Pavlovian aversive conditioning requires learning of the association between a conditioned stimulus (CS) and an unconditioned, aversive stimulus (US) but also involves encoding the time interval between the two stimuli. The neurobiological bases of this time interval learning are unknown. Here, we show that in rats, the dorsal striatum and basal amygdala belong to a common functional network underlying temporal expectancy and learning of a CS-US interval. Importantly, changes in coherence between striatum and amygdala local field potentials (LFPs) were found to couple these structures during interval estimation within the lower range of the theta rhythm (3-6 Hz). Strikingly, we also show that a change to the CS-US time interval results in long-term changes in cortico-striatal synaptic efficacy under the control of the amygdala. Collectively, this study reveals physiological correlates of plasticity mechanisms of interval timing that take place in the striatum and are regulated by the amygdala.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.