ArticleDiagnostic and interventional radiology (Ankara, Turkey)
Pulmonary fibrosis: tissue characterization using late-enhanced MRI compared with unenhanced anatomic high-resolution CT.
Article in Diagnostic and interventional radiology (Ankara, Turkey). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The use of chest magnetic resonance imaging in interstitial lung disease: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2018Pooled it
- Dynamic contrast enhanced MRI for the evaluation of lung perfusion in idiopathic pulmonary fibrosis.The European respiratory journal · 2022Trial
- Imaging in animal models: bridging experimental findings and human pathophysiology.Critical care (London, England) · 2025Review
- Diagnosis and monitoring of systemic sclerosis-associated interstitial lung disease using high-resolution computed tomography.Journal of scleroderma and related disorders · 2022Review
- Dynamic contrast-enhanced magnetic resonance imaging of the lung reveals important pathobiology in idiopathic pulmonary fibrosis.ERJ open research · 2021Article
- Quantification of dual-energy CT-derived functional parameters as potential imaging markers for progression of idiopathic pulmonary fibrosis.European radiology · 2021Article
- CT Morphologic Characteristics and Variant Patterns of Interstitial Pulmonary Fibrosis in Systemic Lupus Erythematosus.Radiology. Cardiothoracic imaging · 2021Article
- [Radiological features of interstitial lung diseases].Der Pathologe · 2021Review
- Differentiating combined pulmonary fibrosis and emphysema from pure emphysema: utility of late gadolinium-enhanced MRI.European radiology experimental · 2020Article
- Review
- Quantitative CT-derived vessel metrics in idiopathic pulmonary fibrosis: A structure-function study.Respirology (Carlton, Vic.) · 2019Article
- Novel Imaging Approaches in Systemic Sclerosis-Associated Interstitial Lung Disease.Current rheumatology reports · 2019Review
- Towards quantitative perfusion MRI of the lung in COPD: The problem of short-term repeatability.PloS one · 2018Article
- Evaluating disease severity in idiopathic pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- Heart and Lung Fibrosis in a Patient with COVID-19-Related Myocarditis.Journal of cardiovascular echographyArticle
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe aimed to prospectively evaluate anatomic chest computed tomography (CT) with tissue characterization late gadolinium-enhanced magnetic resonance imaging (MRI) in the evaluation of pulmonary fibrosis (PF).
methodsTwenty patients with idiopathic pulmonary fibrosis (IPF) and twelve control patients underwent late-enhanced MRI and high-resolution CT. Tissue characterization of PF was depicted using a segmented inversion-recovery turbo low-angle shot MRI sequence. Pulmonary arterial blood pool nulling was achieved by nulling main pulmonary artery signal. Images were read in random order by a blinded reader for presence and extent of overall PF (reticulation and honeycombing) at five anatomic levels. Overall extent of IPF was estimated to the nearest 5% as well as an evaluation of the ratios of IPF made up of reticulation and honeycombing. Overall grade of severity was dependent on the extent of reticulation and honeycombing.
resultsNo control patient exhibited contrast enhancement on lung late-enhanced MRI. All IPF patients were identified with late-enhanced MRI. Mean signal intensity of the late-enhanced fibrotic lung was 31.8±10.6 vs. 10.5±1.6 for normal lung regions, P < 0.001, resulting in a percent elevation in signal intensity from PF of 204.8%±90.6 compared with the signal intensity of normal lung. The mean contrast-to-noise ratio was 22.8±10.7. Late-enhanced MRI correlated significantly with chest CT for the extent of PF (R=0.78, P = 0.001) but not for reticulation, honeycombing, or coarseness of reticulation or honeycombing.
conclusionTissue characterization of IPF is possible using inversion recovery sequence thoracic MRI.
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