SynthesisHuman brain mapping2017
Addressing reverse inference in psychiatric neuroimaging: Meta-analyses of task-related brain activation in common mental disorders.
Synthesis in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 8 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- Brain Structural Abnormalities in Addiction Disorders: Transdiagnostic Meta-Analyses.Human brain mapping · 2026Pooled it
- Co-alteration Network Architecture of Major Depressive Disorder: A Multi-modal Neuroimaging Assessment of Large-scale Disease Effects.Neuroinformatics · 2023Pooled it
- Meta-analytical transdiagnostic neural correlates in common pediatric psychiatric disorders.Scientific reports · 2022Pooled it
- Transdiagnostic and disease-specific abnormalities in the default-mode network hubs in psychiatric disorders: A meta-analysis of resting-state functional imaging studies.European psychiatry : the journal of the Association of European Psychiatrists · 2020Pooled it
- Multimodal Abnormalities of Brain Structure and Function in Major Depressive Disorder: A Meta-Analysis of Neuroimaging Studies.The American journal of psychiatry · 2020Pooled it
- Identification of Common Neural Circuit Disruptions in Emotional Processing Across Psychiatric Disorders.The American journal of psychiatry · 2020Pooled it
- Shared Neural Phenotypes for Mood and Anxiety Disorders: A Meta-analysis of 226 Task-Related Functional Imaging Studies.JAMA psychiatry · 2020Pooled it
- Centrality of prefrontal and motor preparation cortices to Tourette Syndrome revealed by meta-analysis of task-based neuroimaging studies.NeuroImage. Clinical · 2017Pooled it
- Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026Review
- Sociability and whole-brain resting-state connectivity.Scientific reports · 2026Article
- Review
- Article
- Coactivation patterns reveal the abnormality of dynamic state transitions between different psychiatric disorders.Scientific reports · 2025Article
- Monotonicity in graph theoretic summaries of fMRI data acquired during human learning.Frontiers in human neuroscience · 2025Article
- Running in the FAMILY: understanding and predicting the intergenerational transmission of mental illness.European child & adolescent psychiatry · 2024Article
- Borderline personality disorder: a comprehensive review of diagnosis and clinical presentation, etiology, treatment, and current controversies.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Robust High-Dimensional Regression with Coefficient Thresholding and its Application to Imaging Data Analysis.Journal of the American Statistical Association · 2024Article
- The mesolimbic system and the loss of higher order network features in schizophrenia when learning without reward.Frontiers in psychiatry · 2024Article
- Functional magnetic resonance imaging study of group independent components underpinning item responses to paranoid-depressive scale.World journal of clinical cases · 2023Article
- Learning without contingencies: A loss of synergy between memory and reward circuits in schizophrenia.Schizophrenia research · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Functional magnetic resonance imaging (fMRI) studies in psychiatry use various tasks to identify case-control differences in the patterns of task-related brain activation. Differently activated regions are often ascribed disorder-specific functions in an attempt to link disease expression and brain function. We undertook a systematic meta-analysis of data from task-fMRI studies to examine the effect of diagnosis and study design on the spatial distribution and direction of case-control differences on brain activation. We mapped to atlas regions coordinates of case-control differences derived from 537 task-fMRI studies in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorders, and obsessive compulsive disorder comprising observations derived from 21,427 participants. The fMRI tasks were classified according to the Research Domain Criteria (RDoC). We investigated whether diagnosis, RDoC domain or construct and use of regions-of-interest or whole-brain analyses influenced the neuroanatomical pattern of results. When considering all primary studies, we found an effect of diagnosis for the amygdala and caudate nucleus and an effect of RDoC domains and constructs for the amygdala, hippocampus, putamen and nucleus accumbens. In contrast, whole-brain studies did not identify any significant effect of diagnosis or RDoC domain or construct. These results resonate with prior reports of common brain structural and genetic underpinnings across these disorders and caution against attributing undue specificity to brain functional changes when forming explanatory models of psychiatric disorders. Hum Brain Mapp 38:1846-1864, 2017. © 2017 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.