Evidence map›Paper›PMID 28066990›Full record

ReviewPediatric blood & cancer2017

Management of adrenal masses in patients with Beckwith-Wiedemann syndrome.

Suzanne P MacFarland, Sogol Mostoufi-Moab, Kristin Zelley, Peter A Mattei, Lisa J States, Tricia R Bhatti, Kelly A Duffy, Garrett M Brodeur, Jennifer M Kalish

Abstract readReview
In one paragraph

Review in Pediatric blood & cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Pathological and Genetic Stratification for Management of Adrenocortical Carcinoma.The Journal of clinical endocrinology and metabolism · 2022
    Review
  5. Pediatric adrenocortical carcinoma.Frontiers in endocrinology · 2022
    Review
  6. Review
  7. Approach to the Patient With Adrenal Incidentaloma.The Journal of clinical endocrinology and metabolism · 2021
    Review
  8. Article
  9. Review
  10. Cushing syndrome: Old and new genes.Best practice & research. Clinical endocrinology & metabolism · 2020
    Review
  11. Beckwith-Wiedemann syndrome in diverse populations.American journal of medical genetics. Part A · 2019
    Article
  12. Adrenocortical adenoma in a Sudanese girl with Beckwith-Wiedemann syndrome.International journal of pediatric endocrinology · 2019
    Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suzanne P MacFarlandDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Sogol Mostoufi-MoabDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Kristin ZelleyDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Peter A MatteiDepartment of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Lisa J StatesDepartment of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Tricia R BhattiDepartment of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Kelly A DuffyDivision of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Garrett M BrodeurDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Jennifer M KalishDepartment of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Funding

T32 Institutional Pediatric ResearchT32HD043021 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Joseph W. St. Geme · 2002 to 2026
$6.4M
Bone Deficits and Excess Adiposity after Pediatric Bone Marrow TransplantationK07CA166177 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI MOSTOUFI-MOAB, SOGOL · 2013 to 2017
$825k
The Mechanism of Tumor Formation in Beckwith-Wiedemann SyndromeK08CA193915 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI KALISH, JENNIFER MELISSA · 2015 to 2019
$703k
NCI NIH HHS K07 CA166177NCI NIH HHS K08 CA193915NICHD NIH HHS T32 HD043021
6 · The paper itself

Abstract

Beckwith-Wiedemann syndrome (BWS) is a genetic overgrowth and cancer predisposition syndrome, associated with both benign and malignant adrenal findings. Literature review and an institutional case series elucidate the wide spectrum of adrenal findings in BWS patients. The altered expression of the 11p15 region is likely related to adrenal gland hyperplasia and growth dysregulation. Given the absence of guidelines for managing adrenal findings in BWS, we propose a systematic approach to adrenal findings in BWS patients, to allow for maximum detection of potentially malignant pathology without posing additional risk to patients.

Indexed as

Adrenal Gland DiseasesBeckwith-Wiedemann SyndromeHumans11p overgrowthadrenal cytomegalyadrenal massBeckwith-Wiedemann syndromecancer predispositionisolated hemihypertrophytumor screening

Identifiers

PMID28066990
PMCPMC5944603

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.