Evidence map›Paper›PMID 28066962›Full record

ArticleTropical medicine & international health : TM & IH2017

Outcomes among HIV-infected children initiating HIV care and antiretroviral treatment in Ethiopia.

Zenebe Melaku, Sileshi Lulseged, Chunhui Wang, Matthew R Lamb, Yoseph Gutema, Chloe A Teasdale, Solomon Ahmed, Tsigereda Gadisa, Zelalem Habtamu, Abubaker Bedri and 2 more

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In one paragraph

Article in Tropical medicine & international health : TM & IH, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zenebe MelakuICAP in Ethiopia, Addis Ababa, Ethiopia.
Sileshi LulsegedICAP in Ethiopia, Addis Ababa, Ethiopia.
Chunhui WangICAP, Mailman School of Public Health, Columbia University, New York, NY, USA.
Matthew R LambICAP, Mailman School of Public Health, Columbia University, New York, NY, USA.
Yoseph GutemaICAP in Ethiopia, Addis Ababa, Ethiopia.
Chloe A TeasdaleICAP, Mailman School of Public Health, Columbia University, New York, NY, USA.
Solomon AhmedCenters for Disease Control and Prevention, Addis Ababa, Ethiopia.
Tsigereda GadisaICAP in Ethiopia, Addis Ababa, Ethiopia.
Zelalem HabtamuOromia Regional Health Bureau, Addis Ababa, Ethiopia.
Abubaker BedriCenters for Disease Control and Prevention, Addis Ababa, Ethiopia.
Ruby FayorseyICAP, Mailman School of Public Health, Columbia University, New York, NY, USA.
Elaine J AbramsICAP, Mailman School of Public Health, Columbia University, New York, NY, USA.

Funding

NCHHSTP CDC HHS U2G PS001537NCHHSTP CDC HHS U62 PS223540
6 · The paper itself

Abstract

objectiveTo describe pediatric ART scale-up in Ethiopia, one of the 21 global priority countries for elimination of pediatric HIV infection.

methodsA descriptive analysis of routinely collected HIV care and treatment data on HIV-infected children (<15 years) enrolled at 70 health facilities in four regions in Ethiopia, January 2006-September 2013. Characteristics at enrollment and ART initiation are described along with outcomes at 1 year after enrollment. Among children who initiated ART, cumulative incidence of death and loss to follow-up (LTF) were estimated using survival analysis.

results11 695 children 0-14 years were enrolled in HIV care and 6815 (58.3%) initiated ART. At enrollment, 31.2% were WHO stage III and 6.3% stage IV. The majority (87.9%) were enrolled in secondary or tertiary facilities. At 1 year after enrollment, 17.9% of children were LTF prior to ART initiation. Among children initiating ART, cumulative incidence of death was 3.4%, 4.1% and 4.8%, and cumulative incidence of LTF was 7.7%, 11.8% and 16.6% at 6, 12 and 24 months, respectively. Children <2 years had higher risk of LTF and death than older children (P < 0.0001). Children with more advanced disease and those enrolled in rural settings were more likely to die. Children enrolled in more recent years were less likely to die but more likely to be LTF.

conclusionsOver the last decade large numbers of HIV-infected children have been successfully enrolled in HIV care and initiated on ART in Ethiopia. Retention prior to and after ART initiation remains a major challenge.

Indexed as

HIV InfectionsLost to Follow-UpAdolescentAnti-HIV AgentsAnti-Retroviral AgentsChildChild, PreschoolEthiopiaFemaleFollow-Up StudiesHumansInfantInfant, NewbornMaleRisk FactorsRural PopulationAnti-HIV AgentsAnti-Retroviral Agentsampliación del TARantiretroviral treatmentART scale-updéploiement de l’ARTEthiopiaEthiopieEtiopíaHIV retentionpaediatric HIVretención en VIHrétention VIHtraitement antirétroviraltratamiento antirretroviralVIH pediátricoVIH pédiatrique

Identifiers

PMID28066962
PMCPMC11541046

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.