Evidence map›Paper›PMID 28066794›Full record

ArticleOpen forum infectious diseases2016

Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection.

Manjusha Kulkarni, Emily Bowman, Janelle Gabriel, Taylor Amburgy, Elizabeth Mayne, David A Zidar, Courtney Maierhofer, Abigail Norris Turner, Jose A Bazan, Susan L Koletar and 3 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 41 citations in OpenAlex.

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  17. Cytomegalovirus Coinfection Is Associated with Increased Vascular-Homing CD57Journal of immunology (Baltimore, Md. : 1950) · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Manjusha KulkarniSchool of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University , Columbus.
Emily BowmanSchool of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University , Columbus.
Janelle GabrielSchool of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University , Columbus.
Taylor AmburgySchool of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University , Columbus.
Elizabeth MayneNational Health Laboratory Service and Faculty of Health Sciences, University of Witwatersrand , Johannesburg.
David A ZidarHarrington Heart & Vascular Institute, University Hospitals Case Medical Center , Cleveland, Ohio.
Courtney MaierhoferDepartment of Medicine, Division of Infectious Diseases, Ohio State University , Columbus.
Abigail Norris TurnerDepartment of Medicine, Division of Infectious Diseases, Ohio State University , Columbus.
Jose A BazanDepartment of Medicine, Division of Infectious Diseases, Ohio State University , Columbus.
Susan L KoletarDepartment of Medicine, Division of Infectious Diseases, Ohio State University , Columbus.
Michael M LedermanDepartment of Internal Medicine, Division of Infectious Diseases, Case Western Reserve University/University Hospitals of Cleveland , Ohio.
Scott F SiegDepartment of Internal Medicine, Division of Infectious Diseases, Case Western Reserve University/University Hospitals of Cleveland , Ohio.
Nicholas T FunderburgSchool of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University , Columbus.
The Ohio State University · USCase Western Reserve University · USNational Health Laboratory Service · ZAUniversity Hospitals Case Medical Center · USUniversity Hospitals of Cleveland · US

Funding

Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8M
University of Pittsburgh Clinical Trials UnitUM1AI069494 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SUSAN L KOLETAR, John W Mellors · 2012 to 2026
$38.0M
Cellular mediators of vascular inflammation in treated HIV-infectionR01HL134544 · NHLBI · OHIO STATE UNIVERSITY · PI FUNDERBURG, NICHOLAS T. · 2016 to 2019
$3.2M
NHLBI NIH HHS R01 HL134544NIAID NIH HHS UM1 AI069494NIAID NIH HHS UM1 AI106701
6 · The paper itself

Abstract

backgroundHuman immunodeficiency virus (HIV)-infected individuals have increased risk for vascular thrombosis, potentially driven by interactions between activated leukocytes and the endothelium.

methodsMonocyte subsets (CD14

resultsProportions of CD16

conclusionsIncreased proportions of CD16

Indexed as

adhesion moleculesfractalkineHIVlipoprotein-associated phospholipase A2monocytes.

Identifiers

PMID28066794
PMCPMC5198584
OpenAlexW2561934627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.