Evidence map›Paper›PMID 28066791›Full record

ArticleJournal of biological methods2016

A practical approach to remote ischemic preconditioning and ischemic preconditioning against myocardial ischemia/reperfusion injury.

Matthias Totzeck, Ulrike B Hendgen-Cotta, Brent A French, Tienush Rassaf

Open access · diamondAbstract read
In one paragraph

Article in Journal of biological methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Guidelines for measuring cardiac physiology in mice.American journal of physiology. Heart and circulatory physiology · 2018
    Guideline
  2. Article
  3. Article
  4. Article
  5. CD47 blockade enhances phagocytosis of cardiac cell debris by neutrophils.International journal of cardiology. Heart & vasculature · 2023
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Matthias TotzeckDepartment of Cardiology and Department of Angiology, West German Heart and Vascular Center, Medical Faculty, University Hospital Essen, Essen 45147, Germany.
Ulrike B Hendgen-CottaDepartment of Cardiology and Department of Angiology, West German Heart and Vascular Center, Medical Faculty, University Hospital Essen, Essen 45147, Germany.
Brent A FrenchDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22903, USA.
Tienush RassafDepartment of Cardiology and Department of Angiology, West German Heart and Vascular Center, Medical Faculty, University Hospital Essen, Essen 45147, Germany.
Essen University Hospital · DEUniversity of Virginia · USWest German Heart and Vascular Center Essen · DE

Funding

Inflammation and Oxidative Stress in Hyperglycemic Exacerbation of Infarct SizeR01HL092305 · NHLBI · UNIVERSITY OF VIRGINIA · PI FRENCH, BRENT A, KRON, IRVING L. · 2009 to 2013
$1.9M
Multi-parameter CMR of post-MI Left Ventricular Remodeling in Gene Modified MiceR01HL115225 · NHLBI · UNIVERSITY OF VIRGINIA · PI FRENCH, BRENT A · 2013 to 2016
$1.5M
A2a ADENOSINE RECEPTOR IN REMOTE LV DYSFUNCTION POST-MIR01HL069494 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI FRENCH, BRENT A · 2001 to 2004
$1.5M
NHLBI NIH HHS R01 HL069494NHLBI NIH HHS R01 HL092305NHLBI NIH HHS R01 HL115225
6 · The paper itself

Abstract

Although urgently needed in clinical practice, a cardioprotective therapeutic approach against myocardial ischemia/ reperfusion injury remains to be established. Remote ischemic preconditioning (rIPC) and ischemic preconditioning (IPC) represent promising tools comprising three entities: the generation of a protective signal, the transfer of the signal to the target organ, and the response to the transferred signal resulting in cardioprotection. However, in light of recent scientific advances, many controversies arise regarding the efficacy of the underlying signaling. We here show methods for the generation of the signaling cascade by rIPC as well as IPC in a mouse model for

Indexed as

laser Doppler perfusion imagingmagnetic resonance imagingmyocardial ischemia/reperfusionplasma transferremote ischemic preconditiong

Identifiers

PMID28066791
PMCPMC5218813
OpenAlexW2548800021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.