ArticleNeuroImage. Clinical2017
Initial and sustained brain responses to threat anticipation in blood-injection-injury phobia.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cortical and Subcortical Brain Alterations in Specific Phobia and Its Animal and Blood-Injection-Injury Subtypes: A Mega-Analysis From the ENIGMA Anxiety Working Group.The American journal of psychiatry · 2024Pooled it
- ROI and phobias: The effect of ROI approach on an ALE meta-analysis of specific phobias.Human brain mapping · 2019Pooled it
- Anticipatory attentional avoidance in learned threat associations.Psychological research · 2026Article
- Impact of NPSR1 gene variation on the neural correlates of phasic and sustained fear in spider phobia-an imaging genetics and independent replication approach.Social cognitive and affective neuroscience · 2024Article
- Predicting vasovagal reactions to needles with anticipatory facial temperature profiles.Scientific reports · 2023Article
- Characterizing the neural circuitry associated with configural threat learning.Brain research · 2019Article
- Social anxiety is associated with BNST response to unpredictability.Depression and anxiety · 2019Article
- (Why) Do You Like Scary Movies? A Review of the Empirical Research on Psychological Responses to Horror Films.Frontiers in psychology · 2019Review
- Direct neurophysiological evidence for a role of the human anterior cingulate cortex in central command.Autonomic neuroscience : basic & clinical · 2019Article
- Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls.NeuroImage. Clinical · 2019Article
- Multimodal canonical correlation reveals converging neural circuitry across trauma-related disorders of affect and cognition.Neurobiology of stress · 2018Article
- Activity alterations in the bed nucleus of the stria terminalis and amygdala during threat anticipation in generalized anxiety disorder.Social cognitive and affective neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood-injection-injury (BII) phobia differs from other subtypes of specific phobia in that it is associated with elevated disgust-sensitivity as well as specific autonomic and brain responses during processing of phobia-relevant stimuli. To what extent these features play a role already during threat anticipation is unclear. In the current fMRI experiment, 16 female BII phobics and 16 female healthy controls anticipated the presentation of phobia-specific and neutral pictures. On the behavioral level, anxiety dominated the anticipatory period in BII phobics relative to controls, while both anxiety and disgust were elevated during picture presentation. By applying two different models for the analysis of brain responses to anticipation of phobia-specific versus neutral stimuli, we found initial and sustained increases of activation in anterior cingulate cortex (ACC), insula, lateral and medial prefrontal cortex (PFC), thalamus and visual areas, as well as initial activation in the amygdala for BII phobics as compared to healthy controls. These results suggest that BII phobia is characterized by activation of a typical neural defense network during threat anticipation, with anxiety as the predominant emotion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.