ArticleJournal of thoracic disease2016
Serum uric acid levels and cardiovascular disease: the Gordian knot.
Article in Journal of thoracic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Uric Acid Extremes and Lipid Dysregulation: Evidence from a Large Population-Based Study.Metabolites · 2026Article
- Portable Point-of-Care Uric Acid Detection System with Cloud-Based Data Analysis and Patient Monitoring.Biosensors · 2026Article
- The Role of the Intestinal Microbiome in the Pathogenesis and Treatment of Hyperuricemia: A Review.Food science & nutrition · 2025Review
- Uric Acid to Platelet Ratio (UAPR) and Its Link to Lipid Abnormalities: Findings from a Large Cohort Study in Saudi Arabia.Journal of clinical medicine · 2025Article
- Comparison of seven anthropometric indexes to predict hypertension plus hyperuricemia among U.S. adults.Frontiers in endocrinology · 2024Article
- A Cohort Study on the Correlation Between Serum Uric Acid Trajectory and New-Onset Hypertension Based on Longitudinal Health Examination Data in Henan Area.Journal of inflammation research · 2024Article
- The association between serum uric acid and cognitive performance in patients with ischemic stroke is modified by estimated glomerular filtration rate.Scientific reports · 2023Article
- Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Polymorphisms of the genesF1000Research · 2021Article
- Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008-2012).Lipids in health and disease · 2020Article
- The causal role of elevated uric acid and waist circumference on the risk of metabolic syndrome components.International journal of obesity (2005) · 2020Article
- Hyperuricaemia is associated with dyslipidemia but not HbA1c among type 2 diabetes mellitus patients in Botswana.African journal of laboratory medicine · 2019Article
- Effect ofFrontiers in pharmacology · 2019Article
- Antihyperuricemic effect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidase activity and urate transporter 1 expression in mice.Acta pharmaceutica Sinica. B · 2018Article
- Recent advances on uric acid transporters.Oncotarget · 2017Review
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperuricemia is defined as serum uric acid level of more than 7 mg/dL and blood levels of uric acid are causally associated with gout, as implicated by evidence from randomized clinical trials using urate lowering therapies. Uric acid as a cardiovascular risk factor often accompanies metabolic syndrome, hypertension, diabetes, dyslipidemia, chronic renal disease, and obesity. Despite the association of hyperuricemia with cardiovascular risk factors, it has remained controversial as to whether uric acid is an independent predictor of cardiovascular disease. To settle this issue, and in the absence of large randomized controlled trials, Mendelian randomization analysis in which the exposure is defined based on the presence or absence of a specific allele that influences a risk factor of interest have tried to shed light on this.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.