ArticleThe journal of physical chemistry. C, Nanomaterials and interfaces2016
NMR SLIC Sensing of Hydrogenation Reactions Using Parahydrogen in Low Magnetic Fields.
Article in The journal of physical chemistry. C, Nanomaterials and interfaces, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Open-source, partially 3D-printed, high-pressure (50-bar) liquid-nitrogen-cooled parahydrogen generator.Magnetic resonance (Gottingen, Germany) · 2021Article
- Generating and sustaining long-lived spin states inScientific reports · 2019Article
- A versatile synthetic route to the preparation ofJournal of labelled compounds & radiopharmaceuticals · 2019Article
- Monitoring Hydrogenation Reactions using Benchtop 2D NMR with Extraordinary Sensitivity and Spectral Resolution.ChemistryOpen · 2019Article
- Chemical Exchange Reaction Effect on Polarization Transfer Efficiency in SLIC-SABRE.The journal of physical chemistry. A · 2018Article
- Effects of Deuteration ofThe journal of physical chemistry. C, Nanomaterials and interfaces · 2018Article
- Synthesis of Unsaturated Precursors for Parahydrogen-Induced Polarization and Molecular Imaging of 1-ACS omega · 2018Article
- Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization.Angewandte Chemie (International ed. in English) · 2017Article
- NMR Spin-Lock Induced Crossing (SLIC) dispersion and long-lived spin states of gaseous propane at low magnetic field (0.05T).Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Parahydrogen-induced polarization (PHIP) is an NMR hyperpolarization technique that increases nuclear spin polarization by orders of magnitude, and it is particularly well-suited to study hydrogenation reactions. However, the use of high-field NMR spectroscopy is not always possible, especially in the context of potential industrial-scale reactor applications. On the other hand, the direct low-field NMR detection of reaction products with enhanced nuclear spin polarization is challenging due to near complete signal cancellation from nascent parahydrogen protons. We show that hydrogenation products prepared by PHIP can be irradiated with weak (on the order of spin-spin couplings of a few hertz) alternating magnetic field (called Spin-Lock Induced Crossing or SLIC) and consequently efficiently detected at low magnetic field (e.g., 0.05 T used here) using examples of several types of organic molecules containing a vinyl moiety. The detected hyperpolarized signals from several reaction products at tens of millimolar concentrations were enhanced by 10000-fold, producing NMR signals an order of magnitude greater than the background signal from protonated solvents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.