Evidence map›Paper›PMID 28066448›Full record

ReviewFrontiers in immunology2016

Autologous and Allogenous Antibodies in Lung and Islet Cell Transplantation.

Deepak Kumar Nayak, Prathab Balaji Saravanan, Sandhya Bansal, Bashoo Naziruddin, Thalachallour Mohanakumar

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Deepak Kumar NayakNorton Thoracic Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.
Prathab Balaji SaravananBaylor Research Institute , Dallas, TX , USA.
Sandhya BansalNorton Thoracic Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.
Bashoo NaziruddinBaylor Simmons Transplant Institute , Dallas, TX , USA.
Thalachallour MohanakumarNorton Thoracic Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.

Funding

ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)R01HL092514 · NHLBI · WASHINGTON UNIVERSITY · PI MOHANAKUMAR, THALACHALLOUR · 2009 to 2018
$3.0M
NHLBI NIH HHS R01 HL092514
6 · The paper itself

Abstract

The field of organ transplantation has undoubtedly made great strides in recent years. Despite the advances in donor-recipient histocompatibility testing, improvement in transplantation procedures, and development of aggressive immunosuppressive regimens, graft-directed immune responses still pose a major problem to the long-term success of organ transplantation. Elicitation of immune responses detected as antibodies to mismatched donor antigens (alloantibodies) and tissue-restricted self-antigens (autoantibodies) are two major risk factors for the development of graft rejection that ultimately lead to graft failure. In this review, we describe current understanding on genesis and pathogenesis of antibodies in two important clinical scenarios: lung transplantation and transplantation of islet of Langerhans. It is evident that when compared to any other clinical solid organ or cellular transplant, lung and islet transplants are more susceptible to rejection by combination of allo- and autoimmune responses.

Indexed as

antibodygraft rejectionislet of Langerhanslungtransplantation

Identifiers

PMID28066448
PMCPMC5179571

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.