Evidence map›Paper›PMID 28066416›Full record

ArticleFrontiers in immunology2016

Distinct Patterns of Tryptophan Maintenance in Tissues during Kynurenine Pathway Activation in Simian Immunodeficiency Virus-Infected Macaques.

Julia L Drewes, Joshua D Croteau, Erin N Shirk, Elizabeth L Engle, M C Zink, David R Graham

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Indoleamine 2,3-Dioxygenase Cannot InhibitFrontiers in immunology · 2021
    Article
  4. Article
  5. Review
  6. In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control ofProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Julia L DrewesDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
Joshua D CroteauDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
Erin N ShirkDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
Elizabeth L EngleDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
M C ZinkDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
David R GrahamDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Project 4: Intracellular mechanism of virus persistence in astrocytes/macrophagesP01MH070306 · NIMH · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E · 2004 to 2015
$16.0M
Viral Testing CoreU42OD013117 · OD · JOHNS HOPKINS UNIVERSITY · PI Lydia Hopper · 2017 to 2026
$10.9M
Development of an SPF Macaca nemestrina Breeding ColonyP40OD013117 · OD · JOHNS HOPKINS UNIVERSITY · PI ADAMS, ROBERT J. · 2012 to 2016
$4.9M
Minocycline Immune Effects on SIV CNS DiseaseR01MH087233 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GRAHAM, DAVID R. M., ZINK, M CHRISTINE · 2010 to 2014
$3.0M
IDO Regulation in the SIV Model of HIV CNS DiseaseR01MH085554 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ZINK, M CHRISTINE · 2009 to 2013
$2.9M
NIH HHS P40 OD013117NIH HHS U42 OD013117NIMH NIH HHS P01 MH070306NIMH NIH HHS R01 MH085554NIMH NIH HHS R01 MH087233
6 · The paper itself

Abstract

Induction of the kynurenine pathway (KP) of tryptophan (TRP) catabolism has been proposed to contribute to T cell dysfunction during human/simian immunodeficiency virus (SIV) infection

Indexed as

HIVIDO1immunosuppressionkynurenineSIVspleentryptophan

Identifiers

PMID28066416
PMCPMC5165277
OpenAlexW2567137057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.